A putative G-protein-coupled receptor, H218, is down-regulated during the retinoic acid-induced differentiation of F9 embryonal carcinoma cells

Yong Li, A. John MacLennan, Melissa B. Rogers

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

We have previously cloned a novel guanine nucleotide-binding protein (G- protein)-coupled receptor, H218, that has sequence similarity to a lysophosphatidic acid receptor, edg2. We present here Northern analysis indicating that the H218 mRNA is expressed in undifferentiated F9 embryonal carcinoma cells. The H218 message is down-regulated and its stability is decreased during retinoic acid- and dibutyryl cAMP-induced differentiation. Treatment by various receptor-selective retinoids indicated that retinoic acid receptor β or γ signaling, but not retinoid X receptor activation, is required for the down-regulation of H218 mRNA. Activation of the H218 receptor may contribute to the phenotype of undifferentiated F9 embryonal carcinoma cells.

Original languageEnglish (US)
Pages (from-to)320-325
Number of pages6
JournalExperimental cell research
Volume239
Issue number2
DOIs
StatePublished - Mar 15 1998
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cell Biology

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