TY - JOUR
T1 - A Twenty-Year Analysis of Demographics, Surgical Management, and Outcomes of Aortic Stenosis in New Jersey
AU - for the Myocardial Infarction Data Acquisition System (MIDAS 41) study group
AU - Hiltner, Emily
AU - Zinonos, Stavros
AU - Kostis, John B.
AU - Cabrera, Javier
AU - Cosgrove, Nora M.
AU - Moreyra, Abel E.
AU - Moussa, Issam
AU - Kostis, William J.
N1 - Funding Information: Funding: Partially funded in part by the Robert Wood Johnson Foundation . Publisher Copyright: © 2021 Elsevier Inc.
PY - 2021/7/1
Y1 - 2021/7/1
N2 - We investigated the incidence and characteristics of 14,996 patients with aortic stenosis (AS) who were hospitalized in New Jersey between the years 1995 to 2015. The average age was 72, the majority were Caucasian males and common co-morbidities were hypertension, coronary artery disease and hypercholesterolemia. Hospital admission for AS declined between 1995 to 2007, to 10/100,000 patients, and increased to 15/100,000 patients in 2015 (p for trend <0.001). During the study period, the percentage of patients who received aortic valve replacement (AVR) increased (p <0.001). All-cause and cardiovascular mortality were higher among patients who did not undergo AVR at 1-year (HR 1.98 CI 1.75 to 2.23, p <0.001 and HR 1.82 CI 1.57 to 2.11, p <0.001, respectively) and 3-years (HR 2.16 CI 1.96 to 2.38, p <0.001 and HR 2.16 CI 1.90 to 2.45, p <0.001, respectively). The probability for readmission for AS was higher in patients who did not receive AVR compared to patients who had AVR at 1 year (HR 92.95 CI 57.85 to 149.35, p <0.001) and 3 years (HR 70.36 CI 47.18 to 104.95, p <0.001). These data imply that earlier diagnosis of AS and AVR when indicated will improve outcomes.
AB - We investigated the incidence and characteristics of 14,996 patients with aortic stenosis (AS) who were hospitalized in New Jersey between the years 1995 to 2015. The average age was 72, the majority were Caucasian males and common co-morbidities were hypertension, coronary artery disease and hypercholesterolemia. Hospital admission for AS declined between 1995 to 2007, to 10/100,000 patients, and increased to 15/100,000 patients in 2015 (p for trend <0.001). During the study period, the percentage of patients who received aortic valve replacement (AVR) increased (p <0.001). All-cause and cardiovascular mortality were higher among patients who did not undergo AVR at 1-year (HR 1.98 CI 1.75 to 2.23, p <0.001 and HR 1.82 CI 1.57 to 2.11, p <0.001, respectively) and 3-years (HR 2.16 CI 1.96 to 2.38, p <0.001 and HR 2.16 CI 1.90 to 2.45, p <0.001, respectively). The probability for readmission for AS was higher in patients who did not receive AVR compared to patients who had AVR at 1 year (HR 92.95 CI 57.85 to 149.35, p <0.001) and 3 years (HR 70.36 CI 47.18 to 104.95, p <0.001). These data imply that earlier diagnosis of AS and AVR when indicated will improve outcomes.
UR - http://www.scopus.com/inward/record.url?scp=85106239485&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85106239485&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2021.03.046
DO - 10.1016/j.amjcard.2021.03.046
M3 - Article
C2 - 34006369
SN - 0002-9149
VL - 150
SP - 82
EP - 88
JO - American Journal of Cardiology
JF - American Journal of Cardiology
ER -