Absence of Aminonucleoside-sensitive Steps in the Cell Cycle of SV40-transformed Human Fibroblasts

John F. Gierthy, George P. Studzinski

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Puromycin aminonucleoside arrests cultured normal human lung fibroblasts in the G1and G2phases of the cell cycle but permits fibroblasts transformed by the oncogenic virus SV40 to continue their cell-cycle traverse. Aminonucleoside has no detectable effect on the entry of the transformed cells into mitosis but it does accelerate the rate of detachment of these cells from the growth surface. These differences were not due to an altered rate of penetration of the membrane of the transformed cells by aminonucleoside.

Original languageEnglish (US)
Pages (from-to)2673-2676
Number of pages4
JournalCancer Research
Volume33
Issue number11
StatePublished - Nov 1973
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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