Abyssomicins G and H and atrop-abyssomicin C from the marine Verrucosispora strain AB-18-032

Simone Keller, Graeme Nicholson, Carmen Drahl, Erik Sorensen, Hans Peter Fiedler, Roderich D. Süssmuth

Research output: Contribution to journalArticlepeer-review

84 Scopus citations

Abstract

Abyssomicin C is a complex polyketide-type antibiotic and the first natural inhibitor of the p-aminobenzoate biosynthesis produced by the marine Verrucosispora strain AB-18-032. We have now isolated three novel naturally produced abyssomicins, among them the even more active atrop-abyssomicin C. The chemical structures were elucidated by mass spectrometry and NMR spectroscopy.

Original languageAmerican English
Pages (from-to)391-394
Number of pages4
JournalJournal of Antibiotics
Volume60
Issue number6
DOIs
StatePublished - Jun 2007

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Keywords

  • Abyssomicins
  • Antibiotics
  • Structure elucidation
  • Tetronic acid
  • Verrucosispora

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