Acid labile ComX pheromone from Bacillus mojavensis RO-H-1

Masahiro Okada, Hisao Yamaguchi, Isao Sato, Fumitada Tsuji, Jianhua Qi, David Dubnau, Youji Sakagami

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Bacillus mojavensis strain RO-H-1 produces a post-translationally modified hexapeptide, the ComXRO-H-1 pheromone, that stimulates natural genetic competence controlled by quorum sensing. LC/ESI-MS analysis of partially purification of the ComXRO-H-1 pheromone suggested a precise modification in its tryptophan residue. The corresponding ComXRO-H-1 pheromone prepared by solid-phase synthesis was identical to the natural pheromone, and showed significant biological activity. These results indicated that the posttranslational modification of the ComXRO-H-1 pheromone was geranylation on the tryptophan residue, resulting in the formation of a tricyclic structure. The ComXRO-H-1 pheromone was immediately dehydrated by acid because of its extreme acid lability.

Original languageEnglish (US)
Pages (from-to)1807-1810
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Issue number7
StatePublished - 2007

All Science Journal Classification (ASJC) codes

  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Molecular Biology
  • Biochemistry
  • Biotechnology
  • Organic Chemistry


  • Bacillus mojavensis
  • ComX
  • Posttranslational modification
  • Quorum sensing
  • Tryptophan


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