TY - JOUR
T1 - Activation of immediate early genes after acute stress
AU - Schreiber, Steven S.
AU - Tocco, Georges
AU - Shors, Tracey J.
AU - Thompson, Richard F.
PY - 1991/1
Y1 - 1991/1
N2 - We used in-situ hybridization to study the effect of acute stress on induction of the immediate early genes (IEGs), c-fos and zif/268, in the rat brain. After one hour of restraint plus intermittent tail shock, messenger RNA (mRNA) levels for both genes were significantly increased bilaterally in the neocortex, particularly in layers IV, V and VI, and in the CA1 region of the hippocampus. This regionally-specific response suggests that IEGs may have a role in the mediation of acute stress responses in the central nervous system.
AB - We used in-situ hybridization to study the effect of acute stress on induction of the immediate early genes (IEGs), c-fos and zif/268, in the rat brain. After one hour of restraint plus intermittent tail shock, messenger RNA (mRNA) levels for both genes were significantly increased bilaterally in the neocortex, particularly in layers IV, V and VI, and in the CA1 region of the hippocampus. This regionally-specific response suggests that IEGs may have a role in the mediation of acute stress responses in the central nervous system.
KW - Acute stress
KW - Immediate early genes
KW - In-situ hybridization
KW - Induction
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U2 - https://doi.org/10.1097/00001756-199101000-00004
DO - https://doi.org/10.1097/00001756-199101000-00004
M3 - Article
C2 - 1768844
VL - 2
SP - 17
EP - 20
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 1
ER -