Acute in-vivo testing of the intravenous membrane oxygenator (IMO)

J. F. Golob; W. J. Federspiel; T. L. Merrill; B. J. Frankowski; H. J. Russian; K. Litwak; B. G. Hattler

doi:https://doi.org/10.1097/00002480-200003000-00119

Acute in-vivo testing of the intravenous membrane oxygenator (IMO)

J. F. Golob, W. J. Federspiel, T. L. Merrill, B. J. Frankowski, H. J. Russian, K. Litwak, B. G. Hattler

Mechanical Engineering

Rowan University

Research output: Contribution to journal › Conference article › peer-review

1 Scopus citations

Abstract

Current treatment for acute respiratory failure (ARF) includes the use of mechanical ventilation (MV) and/or extracorporeal membrane oxygenation (ECMO), both of which can exacerbate lung injury. Intravascular oxygenation, using hollow fiber membranes placed in the vena cava, represents a possible support modality for treatment of ARF, while avoiding ventilator induced trauma and other problems. Our group has been actively developing the Intravenous Membrane Oxygenator (IMO), which consists of a constrained fiber bundle with a centrally located balloon. The balloon can be pulsated rapidly to decrease diffusional transfer resistance at the fibers, and increase gas exchange. The purpose of this study was to evaluate the IMO performance during acute implantation in the vena cava and compare performance to that achieved in previous ex-vivo loop studies. The IMO was implanted into four calves via the external jugular vein and placed in the superior and inferior vena cava spanning the right atrium. Gas exchange, hemodynamics and hematological parameters were assessed as balloon pulsation rates were varied from 30 to 300 beats/minute. Post insertion cardiac output ranged from 10 to 14L/minute with less than a 10% reduction pre versus post seen in each experiment. Maximum CO₂ exchange rate occurred at the highest pulsation rate and averaged 327±15 ml/min/m², similar to levels achieved in our ex-vivo studies. The rate of CO₂ transfer with no pulsation was 251±28ml/min/m². Balloon pulsation enhanced gas exchange less during acute implantation than in our ex-vivo loop studies, which can be attributed to the higher flow rates past the device seen in acute implantation.

Original language	American English
Number of pages	1
Journal	ASAIO Journal
Volume	46
Issue number	2
DOIs	https://doi.org/10.1097/00002480-200003000-00119
State	Published - Jan 1 2000
Event	46th Annual Conference and Exposition of ASAIO - New York, NY, USA Duration: Jun 28 2000 → Jul 1 2000

ASJC Scopus subject areas

Biophysics
Bioengineering
Biomaterials
Biomedical Engineering

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https://doi.org/10.1097/00002480-200003000-00119

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title = "Acute in-vivo testing of the intravenous membrane oxygenator (IMO)",

abstract = "Current treatment for acute respiratory failure (ARF) includes the use of mechanical ventilation (MV) and/or extracorporeal membrane oxygenation (ECMO), both of which can exacerbate lung injury. Intravascular oxygenation, using hollow fiber membranes placed in the vena cava, represents a possible support modality for treatment of ARF, while avoiding ventilator induced trauma and other problems. Our group has been actively developing the Intravenous Membrane Oxygenator (IMO), which consists of a constrained fiber bundle with a centrally located balloon. The balloon can be pulsated rapidly to decrease diffusional transfer resistance at the fibers, and increase gas exchange. The purpose of this study was to evaluate the IMO performance during acute implantation in the vena cava and compare performance to that achieved in previous ex-vivo loop studies. The IMO was implanted into four calves via the external jugular vein and placed in the superior and inferior vena cava spanning the right atrium. Gas exchange, hemodynamics and hematological parameters were assessed as balloon pulsation rates were varied from 30 to 300 beats/minute. Post insertion cardiac output ranged from 10 to 14L/minute with less than a 10% reduction pre versus post seen in each experiment. Maximum CO2 exchange rate occurred at the highest pulsation rate and averaged 327±15 ml/min/m2, similar to levels achieved in our ex-vivo studies. The rate of CO2 transfer with no pulsation was 251±28ml/min/m2. Balloon pulsation enhanced gas exchange less during acute implantation than in our ex-vivo loop studies, which can be attributed to the higher flow rates past the device seen in acute implantation.",

author = "Golob, {J. F.} and Federspiel, {W. J.} and Merrill, {T. L.} and Frankowski, {B. J.} and Russian, {H. J.} and K. Litwak and Hattler, {B. G.}",

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T1 - Acute in-vivo testing of the intravenous membrane oxygenator (IMO)

AU - Golob, J. F.

AU - Federspiel, W. J.

AU - Merrill, T. L.

AU - Frankowski, B. J.

AU - Russian, H. J.

AU - Litwak, K.

AU - Hattler, B. G.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Current treatment for acute respiratory failure (ARF) includes the use of mechanical ventilation (MV) and/or extracorporeal membrane oxygenation (ECMO), both of which can exacerbate lung injury. Intravascular oxygenation, using hollow fiber membranes placed in the vena cava, represents a possible support modality for treatment of ARF, while avoiding ventilator induced trauma and other problems. Our group has been actively developing the Intravenous Membrane Oxygenator (IMO), which consists of a constrained fiber bundle with a centrally located balloon. The balloon can be pulsated rapidly to decrease diffusional transfer resistance at the fibers, and increase gas exchange. The purpose of this study was to evaluate the IMO performance during acute implantation in the vena cava and compare performance to that achieved in previous ex-vivo loop studies. The IMO was implanted into four calves via the external jugular vein and placed in the superior and inferior vena cava spanning the right atrium. Gas exchange, hemodynamics and hematological parameters were assessed as balloon pulsation rates were varied from 30 to 300 beats/minute. Post insertion cardiac output ranged from 10 to 14L/minute with less than a 10% reduction pre versus post seen in each experiment. Maximum CO2 exchange rate occurred at the highest pulsation rate and averaged 327±15 ml/min/m2, similar to levels achieved in our ex-vivo studies. The rate of CO2 transfer with no pulsation was 251±28ml/min/m2. Balloon pulsation enhanced gas exchange less during acute implantation than in our ex-vivo loop studies, which can be attributed to the higher flow rates past the device seen in acute implantation.

AB - Current treatment for acute respiratory failure (ARF) includes the use of mechanical ventilation (MV) and/or extracorporeal membrane oxygenation (ECMO), both of which can exacerbate lung injury. Intravascular oxygenation, using hollow fiber membranes placed in the vena cava, represents a possible support modality for treatment of ARF, while avoiding ventilator induced trauma and other problems. Our group has been actively developing the Intravenous Membrane Oxygenator (IMO), which consists of a constrained fiber bundle with a centrally located balloon. The balloon can be pulsated rapidly to decrease diffusional transfer resistance at the fibers, and increase gas exchange. The purpose of this study was to evaluate the IMO performance during acute implantation in the vena cava and compare performance to that achieved in previous ex-vivo loop studies. The IMO was implanted into four calves via the external jugular vein and placed in the superior and inferior vena cava spanning the right atrium. Gas exchange, hemodynamics and hematological parameters were assessed as balloon pulsation rates were varied from 30 to 300 beats/minute. Post insertion cardiac output ranged from 10 to 14L/minute with less than a 10% reduction pre versus post seen in each experiment. Maximum CO2 exchange rate occurred at the highest pulsation rate and averaged 327±15 ml/min/m2, similar to levels achieved in our ex-vivo studies. The rate of CO2 transfer with no pulsation was 251±28ml/min/m2. Balloon pulsation enhanced gas exchange less during acute implantation than in our ex-vivo loop studies, which can be attributed to the higher flow rates past the device seen in acute implantation.

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SN - 0066-0078

VL - 46

JO - Transactions - American Society for Artificial Internal Organs

JF - Transactions - American Society for Artificial Internal Organs

IS - 2

T2 - 46th Annual Conference and Exposition of ASAIO

Y2 - 28 June 2000 through 1 July 2000

ER -

Acute in-vivo testing of the intravenous membrane oxygenator (IMO)

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