Addiction neuroscience goes nuclear: A role for the transcription factor RXRα

R. Christopher Pierce; Matthew T. Rich; Sarah E. Swinford-Jackson

doi:10.1016/j.neuron.2023.04.002

Addiction neuroscience goes nuclear: A role for the transcription factor RXRα

R. Christopher Pierce, Matthew T. Rich, Sarah E. Swinford-Jackson

Robert Wood Johnson Medical School (RWJMS), Psychiatry

Rutgers, The State University

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Building on work defining the cocaine-modulated transcriptional landscape in mice, Godino and colleagues focus in this issue of Neuron¹ on the role of a specific nuclear receptor, RXRα. Results demonstrate that modifying accumbens RXRα expression profoundly alters gene transcription, neuronal activity, and cocaine-induced behavioral responses.

Original language	English (US)
Pages (from-to)	1351-1353
Number of pages	3
Journal	Neuron
Volume	111
Issue number	9
DOIs	https://doi.org/10.1016/j.neuron.2023.04.002
State	Published - May 3 2023

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1016/j.neuron.2023.04.002

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title = "Addiction neuroscience goes nuclear: A role for the transcription factor RXRα",

abstract = "Building on work defining the cocaine-modulated transcriptional landscape in mice, Godino and colleagues focus in this issue of Neuron1 on the role of a specific nuclear receptor, RXRα. Results demonstrate that modifying accumbens RXRα expression profoundly alters gene transcription, neuronal activity, and cocaine-induced behavioral responses.",

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AB - Building on work defining the cocaine-modulated transcriptional landscape in mice, Godino and colleagues focus in this issue of Neuron1 on the role of a specific nuclear receptor, RXRα. Results demonstrate that modifying accumbens RXRα expression profoundly alters gene transcription, neuronal activity, and cocaine-induced behavioral responses.

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Addiction neuroscience goes nuclear: A role for the transcription factor RXRα

Abstract

All Science Journal Classification (ASJC) codes

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