Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins

Alan R. Kimmel, Monica McAndrews-Hill, Carole Sztalryd, Constantine Londos

Research output: Contribution to journalReview article

266 Citations (Scopus)

Abstract

The PAT family of proteins has been identified in eukaryotic species as diverse as vertebrates, insects, and amebazoa. These proteins share a highly conserved sequence organization and avidity for the surfaces of intra cellular, neutral lipid storage droplets. The current nomenclature of the various members lacks consistency and precision, deriving more from historic context than from recognition of evolutionary relationship and shared function. In consultation with the Mouse Genomic Nomenclature Committee, the Human Genome Organization Genomic Nomenclature Committee, and conferees at the 2007 FASEB Conference on Lipid Droplets: Metabolic Consequences of the Storage of Neutral Lipids, we have established a unifying nomenclature for the gene and protein family members. Each gene member will incorporate the root term PERILIPIN (PLIN), the founding gene of the PAT family, with the different genes/proteins numbered sequentially.

Original languageEnglish (US)
Pages (from-to)468-471
Number of pages4
JournalJournal of lipid research
Volume51
Issue number3
DOIs
StatePublished - Mar 1 2010

Fingerprint

Terminology
Lipids
Proteins
Genes
Conserved Sequence
Insects
Vertebrates
Referral and Consultation
Perilipin-1
Lipid Droplet Associated Proteins
Lipid Droplets

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Biochemistry
  • Cell Biology

Keywords

  • Adipocyte differentiationrelated protein
  • Adipophilin
  • Perilipin
  • Tail-interacting protein of 47 kDa

Cite this

Kimmel, Alan R. ; McAndrews-Hill, Monica ; Sztalryd, Carole ; Londos, Constantine. / Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins. In: Journal of lipid research. 2010 ; Vol. 51, No. 3. pp. 468-471.
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Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins. / Kimmel, Alan R.; McAndrews-Hill, Monica; Sztalryd, Carole; Londos, Constantine.

In: Journal of lipid research, Vol. 51, No. 3, 01.03.2010, p. 468-471.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins

AU - Kimmel, Alan R.

AU - McAndrews-Hill, Monica

AU - Sztalryd, Carole

AU - Londos, Constantine

PY - 2010/3/1

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AB - The PAT family of proteins has been identified in eukaryotic species as diverse as vertebrates, insects, and amebazoa. These proteins share a highly conserved sequence organization and avidity for the surfaces of intra cellular, neutral lipid storage droplets. The current nomenclature of the various members lacks consistency and precision, deriving more from historic context than from recognition of evolutionary relationship and shared function. In consultation with the Mouse Genomic Nomenclature Committee, the Human Genome Organization Genomic Nomenclature Committee, and conferees at the 2007 FASEB Conference on Lipid Droplets: Metabolic Consequences of the Storage of Neutral Lipids, we have established a unifying nomenclature for the gene and protein family members. Each gene member will incorporate the root term PERILIPIN (PLIN), the founding gene of the PAT family, with the different genes/proteins numbered sequentially.

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KW - Tail-interacting protein of 47 kDa

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