Adsorption of human salivary mucins to hydroxyapatite

L. A. Tabak, M. J. Levine, N. K. Jain, Amy R. Bryan, R. E. Cohen, Laura D. Monte, S. Zawacki, G. H. Nancollas, Amalia Slomiany, B. L. Slomiany

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74 Scopus citations

Abstract

The interactions between low (MG2) and high (MG1) molecular-weight human submandibular-sublingual mucin and hydroxyapatite (OHAp) were compared using a quantitative assay. Data obtained appeared to empirically fit the Langmuir adsorption isotherm. Apparent affinity constants derived from this isotherm indicated that MG1 had a greater affinity for OHAp than did MG2. Inhibition studies revealed that salivary glycolipids inhibited the interaction of MG1 and OHAp without influencing MG2 adsorption. In contrast, MG2 adsorption to OHAp was markedly inhibited by cysteine-containing salivary phosphoprotein fractions. Collectively, the data indicate MG1 and MG2 differ in their interaction with OHAp.

Original languageEnglish (US)
Pages (from-to)423-427
Number of pages5
JournalArchives of Oral Biology
Volume30
Issue number5
DOIs
StatePublished - 1985
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Dentistry(all)
  • Cell Biology
  • Otorhinolaryngology

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