Adsorption of Macromolecules on Mineral Fibers

Ming J.W. Chang; Laurie B. Joseph; Ralph E. Stephens; Ronald W. Hart

doi:10.3109/10915818309140680

Adsorption of Macromolecules on Mineral Fibers

Ming J.W. Chang
, Laurie B. Joseph
, Ralph E. Stephens
, Ronald W. Hart

Research output: Contribution to journal › Article › peer-review

Abstract

Several mineral fibers were shown to adsorb differentially to three classes of biologically significant macromolecules (i.e., DNA, RNA, and protein). The cytotoxicity exerted by the particulates on a normal human fibroblast cell line, with the exception of attapulgite, correlated positively with the degree of macromolecular adsorption exhibited by these substances, namely: short chrysotile > attapulgite = intermediate chrysotile > amosite > glass fiber. Correspondingly, the ability to interfere with the enzymatic hydrolysis of deoxyribonucleic acid by bovine pancreatic deoxyribonuclease I followed a similar pattern, i.e., chrysotile > amosite = glass fiber. The results suggest that adsorption by mineral fibers may induce changes in enzyme-substrate interactions and therefore could interfere with normal biological processes.

Original language	American English
Pages (from-to)	187-192
Number of pages	6
Journal	International Journal of Toxicology
Volume	2
Issue number	2
DOIs	https://doi.org/10.3109/10915818309140680
State	Published - Mar 1983
Externally published	Yes

ASJC Scopus subject areas

Toxicology

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title = "Adsorption of Macromolecules on Mineral Fibers",

abstract = "Several mineral fibers were shown to adsorb differentially to three classes of biologically significant macromolecules (i.e., DNA, RNA, and protein). The cytotoxicity exerted by the particulates on a normal human fibroblast cell line, with the exception of attapulgite, correlated positively with the degree of macromolecular adsorption exhibited by these substances, namely: short chrysotile > attapulgite = intermediate chrysotile > amosite > glass fiber. Correspondingly, the ability to interfere with the enzymatic hydrolysis of deoxyribonucleic acid by bovine pancreatic deoxyribonuclease I followed a similar pattern, i.e., chrysotile > amosite = glass fiber. The results suggest that adsorption by mineral fibers may induce changes in enzyme-substrate interactions and therefore could interfere with normal biological processes.",

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year = "1983",

month = mar,

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language = "American English",

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TY - JOUR

T1 - Adsorption of Macromolecules on Mineral Fibers

AU - Chang, Ming J.W.

AU - Joseph, Laurie B.

AU - Stephens, Ralph E.

AU - Hart, Ronald W.

PY - 1983/3

Y1 - 1983/3

N2 - Several mineral fibers were shown to adsorb differentially to three classes of biologically significant macromolecules (i.e., DNA, RNA, and protein). The cytotoxicity exerted by the particulates on a normal human fibroblast cell line, with the exception of attapulgite, correlated positively with the degree of macromolecular adsorption exhibited by these substances, namely: short chrysotile > attapulgite = intermediate chrysotile > amosite > glass fiber. Correspondingly, the ability to interfere with the enzymatic hydrolysis of deoxyribonucleic acid by bovine pancreatic deoxyribonuclease I followed a similar pattern, i.e., chrysotile > amosite = glass fiber. The results suggest that adsorption by mineral fibers may induce changes in enzyme-substrate interactions and therefore could interfere with normal biological processes.

AB - Several mineral fibers were shown to adsorb differentially to three classes of biologically significant macromolecules (i.e., DNA, RNA, and protein). The cytotoxicity exerted by the particulates on a normal human fibroblast cell line, with the exception of attapulgite, correlated positively with the degree of macromolecular adsorption exhibited by these substances, namely: short chrysotile > attapulgite = intermediate chrysotile > amosite > glass fiber. Correspondingly, the ability to interfere with the enzymatic hydrolysis of deoxyribonucleic acid by bovine pancreatic deoxyribonuclease I followed a similar pattern, i.e., chrysotile > amosite = glass fiber. The results suggest that adsorption by mineral fibers may induce changes in enzyme-substrate interactions and therefore could interfere with normal biological processes.

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U2 - 10.3109/10915818309140680

DO - 10.3109/10915818309140680

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EP - 192

JO - International Journal of Toxicology

JF - International Journal of Toxicology

IS - 2

ER -

Adsorption of Macromolecules on Mineral Fibers

Abstract

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