Advances in heterologous biosynthesis of plant and fungal natural products by modular co-culture engineering

Tingting Chen, Yiyao Zhou, Yinghua Lu, Haoran Zhang

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Heterologous biosynthesis has been long pursued as a viable approach for high efficiency production of natural products with various industrial values. Conventional methods for heterologous biosynthesis use the mono-culture of an engineered microbe for accommodating the whole target biosynthetic pathway to produce the desired product. The emergence of modular co-culture engineering, which divides the pathway between multiple co-culture strains, presents a new perspective to conduct heterologous biosynthesis and improve the bioproduction performance of natural products. This review highlights recent advances in utilizing the modular co-culture engineering approaches to address the challenges of plant and fungal natural product biosynthesis. Potential directions for future research in this promising field are also discussed.

Original languageEnglish (US)
Pages (from-to)27-34
Number of pages8
JournalBiotechnology Letters
Volume41
Issue number1
DOIs
StatePublished - Jan 15 2019

All Science Journal Classification (ASJC) codes

  • Applied Microbiology and Biotechnology
  • Bioengineering
  • Biotechnology

Keywords

  • Bioproduction improvement
  • Heterologous biosynthesis
  • Modular co-culture engineering
  • Natural product
  • Plants and fungus

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