Age- and disease-related decline in immune function: An opportunity for "Thymus-Boosting" therapies

Francois Berthiaume, Carlos L. Aparicio, John Eungdamrong, Martin Yarmush

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The thymus is the site of production of mature T lymphocytes and thus is indispensable for the development and maintenance of the T cell-mediated arm of the immune system. Thymic production of mature T cells is critically dependent on an influx of bone marrow-derived progenitor T cells that undergo replication and selection within the thymus. Thymus cellularity and thymic hormone secretion reach a peak during the first year of life and then decline gradually until the age of 50-60 years, a process known as "thymic involution." A rapid reduction of thymus cellularity occurs in young patients following injuries, chemotherapy, and other forms of stress. The mechanisms underlying the involution process appear to be dependent on factors intrinsic to the thymic tissue, such as the local production of cytokines and chemoattractants, promoting the recruitment, growth, and differentiation of bone marrow-derived T cell progenitors in the thymus, as well as extrinsic factors, such as systemic levels of endocrine hormones and mediators released by intrathymic nerves of the autonomous nervous system. Knowledge of these factors provides a rational basis for the development of an approach based on tissue engineering that could be used to provide either temporary or permanent reconstitution of thymic function.

Original languageEnglish (US)
Pages (from-to)499-514
Number of pages16
JournalTissue Engineering
Volume5
Issue number6
DOIs
StatePublished - Jan 1 1999

Fingerprint

Thymus
T-cells
Bone
Chemotherapy
Immune system
Hormones
Neurology
Tissue engineering
Tissue

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

@article{ab9fd63edd5e46e590b5a64178a2b5de,
title = "Age- and disease-related decline in immune function: An opportunity for {"}Thymus-Boosting{"} therapies",
abstract = "The thymus is the site of production of mature T lymphocytes and thus is indispensable for the development and maintenance of the T cell-mediated arm of the immune system. Thymic production of mature T cells is critically dependent on an influx of bone marrow-derived progenitor T cells that undergo replication and selection within the thymus. Thymus cellularity and thymic hormone secretion reach a peak during the first year of life and then decline gradually until the age of 50-60 years, a process known as {"}thymic involution.{"} A rapid reduction of thymus cellularity occurs in young patients following injuries, chemotherapy, and other forms of stress. The mechanisms underlying the involution process appear to be dependent on factors intrinsic to the thymic tissue, such as the local production of cytokines and chemoattractants, promoting the recruitment, growth, and differentiation of bone marrow-derived T cell progenitors in the thymus, as well as extrinsic factors, such as systemic levels of endocrine hormones and mediators released by intrathymic nerves of the autonomous nervous system. Knowledge of these factors provides a rational basis for the development of an approach based on tissue engineering that could be used to provide either temporary or permanent reconstitution of thymic function.",
author = "Francois Berthiaume and Aparicio, {Carlos L.} and John Eungdamrong and Martin Yarmush",
year = "1999",
month = "1",
day = "1",
doi = "https://doi.org/10.1089/ten.1999.5.499",
language = "English (US)",
volume = "5",
pages = "499--514",
journal = "Tissue Engineering",
issn = "1076-3279",
publisher = "Mary Ann Liebert Inc.",
number = "6",

}

Age- and disease-related decline in immune function : An opportunity for "Thymus-Boosting" therapies. / Berthiaume, Francois; Aparicio, Carlos L.; Eungdamrong, John; Yarmush, Martin.

In: Tissue Engineering, Vol. 5, No. 6, 01.01.1999, p. 499-514.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Age- and disease-related decline in immune function

T2 - An opportunity for "Thymus-Boosting" therapies

AU - Berthiaume, Francois

AU - Aparicio, Carlos L.

AU - Eungdamrong, John

AU - Yarmush, Martin

PY - 1999/1/1

Y1 - 1999/1/1

N2 - The thymus is the site of production of mature T lymphocytes and thus is indispensable for the development and maintenance of the T cell-mediated arm of the immune system. Thymic production of mature T cells is critically dependent on an influx of bone marrow-derived progenitor T cells that undergo replication and selection within the thymus. Thymus cellularity and thymic hormone secretion reach a peak during the first year of life and then decline gradually until the age of 50-60 years, a process known as "thymic involution." A rapid reduction of thymus cellularity occurs in young patients following injuries, chemotherapy, and other forms of stress. The mechanisms underlying the involution process appear to be dependent on factors intrinsic to the thymic tissue, such as the local production of cytokines and chemoattractants, promoting the recruitment, growth, and differentiation of bone marrow-derived T cell progenitors in the thymus, as well as extrinsic factors, such as systemic levels of endocrine hormones and mediators released by intrathymic nerves of the autonomous nervous system. Knowledge of these factors provides a rational basis for the development of an approach based on tissue engineering that could be used to provide either temporary or permanent reconstitution of thymic function.

AB - The thymus is the site of production of mature T lymphocytes and thus is indispensable for the development and maintenance of the T cell-mediated arm of the immune system. Thymic production of mature T cells is critically dependent on an influx of bone marrow-derived progenitor T cells that undergo replication and selection within the thymus. Thymus cellularity and thymic hormone secretion reach a peak during the first year of life and then decline gradually until the age of 50-60 years, a process known as "thymic involution." A rapid reduction of thymus cellularity occurs in young patients following injuries, chemotherapy, and other forms of stress. The mechanisms underlying the involution process appear to be dependent on factors intrinsic to the thymic tissue, such as the local production of cytokines and chemoattractants, promoting the recruitment, growth, and differentiation of bone marrow-derived T cell progenitors in the thymus, as well as extrinsic factors, such as systemic levels of endocrine hormones and mediators released by intrathymic nerves of the autonomous nervous system. Knowledge of these factors provides a rational basis for the development of an approach based on tissue engineering that could be used to provide either temporary or permanent reconstitution of thymic function.

UR - http://www.scopus.com/inward/record.url?scp=0032765086&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032765086&partnerID=8YFLogxK

U2 - https://doi.org/10.1089/ten.1999.5.499

DO - https://doi.org/10.1089/ten.1999.5.499

M3 - Article

C2 - 10611542

VL - 5

SP - 499

EP - 514

JO - Tissue Engineering

JF - Tissue Engineering

SN - 1076-3279

IS - 6

ER -