Alcohol use and liver cancer mortality in the U.S. (1999–2020): A CDC WONDER analysis.

Izzah Nayyab; Najam Gohar; Faizan Ahmed; Tehmasp Mirza; Abdullah Zia; Aman Ullah; Sherif Eltawansy; Yusra Junaid; Mohamed Bakr; Ammara Fayyaz; Yasir Rashid; Hira Zahid; Kainat Aman; Mohammad Hossain; Areehah Zafar Masood; Mian Zahid Jan Kakakhel; Omar Kamel; Adnan Bhat; Faseeh Haider

doi:10.1200/JCO.2025.43.16_suppl.e13535

Alcohol use and liver cancer mortality in the U.S. (1999–2020): A CDC WONDER analysis.

Izzah Nayyab
, Najam Gohar
, Faizan Ahmed
, Tehmasp Mirza
, Abdullah Zia
, Aman Ullah
, Sherif Eltawansy
, Yusra Junaid
, Mohamed Bakr
, Ammara Fayyaz
, Yasir Rashid
, Hira Zahid
, Kainat Aman
, Mohammad Hossain
, Areehah Zafar Masood
, Mian Zahid Jan Kakakhel
, Omar Kamel
, Adnan Bhat
, Faseeh Haider

School of Medicine

Hackensack Meridian School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

e13535Background: Alcohol consumption is a major risk factor for liver cancer, contributing to preventable mortality. This study examines trends in U.S. alcohol-related liver cancer mortality (1999–2020), stratified by demographics, geography, and socioeconomic factors to identify disparities and guide public health interventions. Methods: Mortality data from CDC WONDER were analyzed for adults aged 35+ from 1999 to 2020. Age-adjusted mortality rates (AAMRs) per million were calculated by gender, race/ethnicity, urbanization, and region. Trends were assessed using Joinpoint regression to determine the average annual percentage change (AAPC) with statistical significance (p-values). Results: Alcohol-related liver cancer caused 30, 222 deaths from 1999 to 2020, with AAMRs increasing from 4.38/million in 1999 to 8.61/million) in 2020 (AAPC: 3.32%; p < 0.000001). Gender: Males (25, 181 deaths, AAMR: 10.65/million) had significantly higher mortality than females (5, 041 deaths, AAMR: 1.92/million). Race: American Indians had the highest AAMR per million(17.4), followed by Hispanics (10.86), Blacks (7.4), and Whites (5.3). The highest AAMR for American Indians was recorded in 2019 (25.86/million). Geography: The South had the most deaths (10, 388), while the West had the highest AAMR (9.22/million). Urban vs. Rural: Rural AAMRs (6.22/million) exceeded urban (5.97/million), with rural mortality rising faster (AAPC: 4.42%; p < 0.000001). Place of death: Most deaths occurred at home (11, 215), followed by inpatient facilities (10, 440). Conclusions: Alcohol-related liver cancer mortality rose significantly from 1999 to 2020, with disparities by gender, race, and geography. Males, American Indians, and rural residents are disproportionately affected. Targeted interventions in high-risk populations are urgently needed.

Original language	English
Pages (from-to)	e13535-e13535
Journal	Journal of Clinical Oncology
Volume	43
DOIs	https://doi.org/10.1200/JCO.2025.43.16_suppl.e13535
State	Published - Jun 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 11 Sustainable Cities and Communities

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1200/JCO.2025.43.16_suppl.e13535

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Nayyab, I., Gohar, N., Ahmed, F., Mirza, T., Zia, A., Ullah, A., Eltawansy, S., Junaid, Y., Bakr, M., Fayyaz, A., Rashid, Y., Zahid, H., Aman, K., Hossain, M., Zafar Masood, A., Kakakhel, M. Z. J., Kamel, O., Bhat, A., & Haider, F. (2025). Alcohol use and liver cancer mortality in the U.S. (1999–2020): A CDC WONDER analysis. Journal of Clinical Oncology, 43, e13535-e13535. https://doi.org/10.1200/JCO.2025.43.16_suppl.e13535

@article{91e593470b6a467bafe5aa8b7a631e3f,

title = "Alcohol use and liver cancer mortality in the U.S. (1999{\textendash}2020): A CDC WONDER analysis.",

abstract = "e13535Background: Alcohol consumption is a major risk factor for liver cancer, contributing to preventable mortality. This study examines trends in U.S. alcohol-related liver cancer mortality (1999{\textendash}2020), stratified by demographics, geography, and socioeconomic factors to identify disparities and guide public health interventions. Methods: Mortality data from CDC WONDER were analyzed for adults aged 35+ from 1999 to 2020. Age-adjusted mortality rates (AAMRs) per million were calculated by gender, race/ethnicity, urbanization, and region. Trends were assessed using Joinpoint regression to determine the average annual percentage change (AAPC) with statistical significance (p-values). Results: Alcohol-related liver cancer caused 30, 222 deaths from 1999 to 2020, with AAMRs increasing from 4.38/million in 1999 to 8.61/million) in 2020 (AAPC: 3.32\%; p < 0.000001). Gender: Males (25, 181 deaths, AAMR: 10.65/million) had significantly higher mortality than females (5, 041 deaths, AAMR: 1.92/million). Race: American Indians had the highest AAMR per million(17.4), followed by Hispanics (10.86), Blacks (7.4), and Whites (5.3). The highest AAMR for American Indians was recorded in 2019 (25.86/million). Geography: The South had the most deaths (10, 388), while the West had the highest AAMR (9.22/million). Urban vs. Rural: Rural AAMRs (6.22/million) exceeded urban (5.97/million), with rural mortality rising faster (AAPC: 4.42\%; p < 0.000001). Place of death: Most deaths occurred at home (11, 215), followed by inpatient facilities (10, 440). Conclusions: Alcohol-related liver cancer mortality rose significantly from 1999 to 2020, with disparities by gender, race, and geography. Males, American Indians, and rural residents are disproportionately affected. Targeted interventions in high-risk populations are urgently needed.",

author = "Izzah Nayyab and Najam Gohar and Faizan Ahmed and Tehmasp Mirza and Abdullah Zia and Aman Ullah and Sherif Eltawansy and Yusra Junaid and Mohamed Bakr and Ammara Fayyaz and Yasir Rashid and Hira Zahid and Kainat Aman and Mohammad Hossain and \{Zafar Masood\}, Areehah and Kakakhel, \{Mian Zahid Jan\} and Omar Kamel and Adnan Bhat and Faseeh Haider",

note = "Publisher Copyright: {\textcopyright} 2025",

year = "2025",

month = jun,

doi = "10.1200/JCO.2025.43.16\_suppl.e13535",

language = "English",

volume = "43",

pages = "e13535--e13535",

journal = "Journal of Clinical Oncology",

issn = "0732-183X",

publisher = "Lippincott Williams and Wilkins",

}

Nayyab, I, Gohar, N, Ahmed, F, Mirza, T, Zia, A, Ullah, A, Eltawansy, S, Junaid, Y, Bakr, M, Fayyaz, A, Rashid, Y, Zahid, H, Aman, K, Hossain, M, Zafar Masood, A, Kakakhel, MZJ, Kamel, O, Bhat, A & Haider, F 2025, 'Alcohol use and liver cancer mortality in the U.S. (1999–2020): A CDC WONDER analysis.', Journal of Clinical Oncology, vol. 43, pp. e13535-e13535. https://doi.org/10.1200/JCO.2025.43.16_suppl.e13535

TY - JOUR

T1 - Alcohol use and liver cancer mortality in the U.S. (1999–2020)

T2 - A CDC WONDER analysis.

AU - Nayyab, Izzah

AU - Gohar, Najam

AU - Ahmed, Faizan

AU - Mirza, Tehmasp

AU - Zia, Abdullah

AU - Ullah, Aman

AU - Eltawansy, Sherif

AU - Junaid, Yusra

AU - Bakr, Mohamed

AU - Fayyaz, Ammara

AU - Rashid, Yasir

AU - Zahid, Hira

AU - Aman, Kainat

AU - Hossain, Mohammad

AU - Zafar Masood, Areehah

AU - Kakakhel, Mian Zahid Jan

AU - Kamel, Omar

AU - Bhat, Adnan

AU - Haider, Faseeh

PY - 2025/6

Y1 - 2025/6

N2 - e13535Background: Alcohol consumption is a major risk factor for liver cancer, contributing to preventable mortality. This study examines trends in U.S. alcohol-related liver cancer mortality (1999–2020), stratified by demographics, geography, and socioeconomic factors to identify disparities and guide public health interventions. Methods: Mortality data from CDC WONDER were analyzed for adults aged 35+ from 1999 to 2020. Age-adjusted mortality rates (AAMRs) per million were calculated by gender, race/ethnicity, urbanization, and region. Trends were assessed using Joinpoint regression to determine the average annual percentage change (AAPC) with statistical significance (p-values). Results: Alcohol-related liver cancer caused 30, 222 deaths from 1999 to 2020, with AAMRs increasing from 4.38/million in 1999 to 8.61/million) in 2020 (AAPC: 3.32%; p < 0.000001). Gender: Males (25, 181 deaths, AAMR: 10.65/million) had significantly higher mortality than females (5, 041 deaths, AAMR: 1.92/million). Race: American Indians had the highest AAMR per million(17.4), followed by Hispanics (10.86), Blacks (7.4), and Whites (5.3). The highest AAMR for American Indians was recorded in 2019 (25.86/million). Geography: The South had the most deaths (10, 388), while the West had the highest AAMR (9.22/million). Urban vs. Rural: Rural AAMRs (6.22/million) exceeded urban (5.97/million), with rural mortality rising faster (AAPC: 4.42%; p < 0.000001). Place of death: Most deaths occurred at home (11, 215), followed by inpatient facilities (10, 440). Conclusions: Alcohol-related liver cancer mortality rose significantly from 1999 to 2020, with disparities by gender, race, and geography. Males, American Indians, and rural residents are disproportionately affected. Targeted interventions in high-risk populations are urgently needed.

AB - e13535Background: Alcohol consumption is a major risk factor for liver cancer, contributing to preventable mortality. This study examines trends in U.S. alcohol-related liver cancer mortality (1999–2020), stratified by demographics, geography, and socioeconomic factors to identify disparities and guide public health interventions. Methods: Mortality data from CDC WONDER were analyzed for adults aged 35+ from 1999 to 2020. Age-adjusted mortality rates (AAMRs) per million were calculated by gender, race/ethnicity, urbanization, and region. Trends were assessed using Joinpoint regression to determine the average annual percentage change (AAPC) with statistical significance (p-values). Results: Alcohol-related liver cancer caused 30, 222 deaths from 1999 to 2020, with AAMRs increasing from 4.38/million in 1999 to 8.61/million) in 2020 (AAPC: 3.32%; p < 0.000001). Gender: Males (25, 181 deaths, AAMR: 10.65/million) had significantly higher mortality than females (5, 041 deaths, AAMR: 1.92/million). Race: American Indians had the highest AAMR per million(17.4), followed by Hispanics (10.86), Blacks (7.4), and Whites (5.3). The highest AAMR for American Indians was recorded in 2019 (25.86/million). Geography: The South had the most deaths (10, 388), while the West had the highest AAMR (9.22/million). Urban vs. Rural: Rural AAMRs (6.22/million) exceeded urban (5.97/million), with rural mortality rising faster (AAPC: 4.42%; p < 0.000001). Place of death: Most deaths occurred at home (11, 215), followed by inpatient facilities (10, 440). Conclusions: Alcohol-related liver cancer mortality rose significantly from 1999 to 2020, with disparities by gender, race, and geography. Males, American Indians, and rural residents are disproportionately affected. Targeted interventions in high-risk populations are urgently needed.

UR - https://www.scopus.com/pages/publications/105024674222

U2 - 10.1200/JCO.2025.43.16_suppl.e13535

DO - 10.1200/JCO.2025.43.16_suppl.e13535

M3 - Review article

SN - 0732-183X

VL - 43

SP - e13535-e13535

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

ER -

Alcohol use and liver cancer mortality in the U.S. (1999–2020): A CDC WONDER analysis.

Abstract

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