Alpha7 nicotinic acetylcholine receptor

A link between inflammation and neurodegeneration

Concepcion Conejero-Goldberg, Peter Davies, Luis Ulloa

Research output: Contribution to journalReview article

58 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is the leading cause of dementia affecting over 25 million people worldwide. Classical studies focused on the description and characterization of the pathological hallmarks found in AD patients including the neurofibrillary tangles and the amyloid plaques. Current strategies focus on the etiology of these hallmarks and the different mechanisms contributing to neurodegeneration. Among them, recent studies reveal the close interplay between the immunological and the neurodegenerative processes. This article examines the implications of the alpha7 nicotinic acetylcholine receptor (alpha7nAChR) as a critical link between inflammation and neurodegeneration in AD. Alpha7nAChRs are not only expressed in neurons but also in Glia cells where they can modulate the immunological responses contributing to AD. Successful therapeutic strategies against AD should consider the connections between inflammation and neurodegeneration. Among them, alpha7nAChR may represent a pharmacological target to control these two mechanisms during the pathogenesis of neurodegenerative and behavioral disorders.

Original languageEnglish (US)
Pages (from-to)693-706
Number of pages14
JournalNeuroscience and Biobehavioral Reviews
Volume32
Issue number4
DOIs
StatePublished - Jan 4 2008
Externally publishedYes

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alpha7 Nicotinic Acetylcholine Receptor
Alzheimer Disease
Inflammation
Neurofibrillary Tangles
Amyloid Plaques
Neuroglia
Neurodegenerative Diseases
Dementia
Pharmacology
Neurons

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

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Alpha7 nicotinic acetylcholine receptor : A link between inflammation and neurodegeneration. / Conejero-Goldberg, Concepcion; Davies, Peter; Ulloa, Luis.

In: Neuroscience and Biobehavioral Reviews, Vol. 32, No. 4, 04.01.2008, p. 693-706.

Research output: Contribution to journalReview article

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