Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis

Xin Zhang; Xiaowen Wang; Ziqiang Yuan; Sarah J. Radford; Chen Liu; Steven K. Libutti; X. F.Steven Zheng

doi:10.1016/j.celrep.2021.108830

Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis

Xin Zhang
, Xiaowen Wang
, Ziqiang Yuan
, Sarah J. Radford
, Chen Liu
, Steven K. Libutti
, X. F.Steven Zheng

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

Abstract

Zhang et al. generate and analyze inducible Rab1A knockout mice. The results reveal that Rab1A-mTORC1 mediates branched chain amino acids signaling and regulates PDX-dependent insulin transcription and beta-cell trans-differentiation to alpha-cells. This amino acid sensing and signaling mechanism controls whole-body glucose homeostasis in mice and men.

Original language	American English
Article number	108830
Journal	Cell Reports
Volume	34
Issue number	11
DOIs	https://doi.org/10.1016/j.celrep.2021.108830
State	Published - Mar 16 2021

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Keywords

PDX1
Rab1A
alpha-cell
amino acids
beta-cell
diabetes
glucose homeostasis
insulin
mTOR
trans-differentiation

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10.1016/j.celrep.2021.108830

Cite this

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title = "Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis",

abstract = "Zhang et al. generate and analyze inducible Rab1A knockout mice. The results reveal that Rab1A-mTORC1 mediates branched chain amino acids signaling and regulates PDX-dependent insulin transcription and beta-cell trans-differentiation to alpha-cells. This amino acid sensing and signaling mechanism controls whole-body glucose homeostasis in mice and men.",

keywords = "PDX1, Rab1A, alpha-cell, amino acids, beta-cell, diabetes, glucose homeostasis, insulin, mTOR, trans-differentiation",

author = "Xin Zhang and Xiaowen Wang and Ziqiang Yuan and Radford, \{Sarah J.\} and Chen Liu and Libutti, \{Steven K.\} and Zheng, \{X. F.Steven\}",

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year = "2021",

month = mar,

day = "16",

doi = "10.1016/j.celrep.2021.108830",

language = "American English",

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TY - JOUR

T1 - Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis

AU - Zhang, Xin

AU - Wang, Xiaowen

AU - Yuan, Ziqiang

AU - Radford, Sarah J.

AU - Liu, Chen

AU - Libutti, Steven K.

AU - Zheng, X. F.Steven

PY - 2021/3/16

Y1 - 2021/3/16

N2 - Zhang et al. generate and analyze inducible Rab1A knockout mice. The results reveal that Rab1A-mTORC1 mediates branched chain amino acids signaling and regulates PDX-dependent insulin transcription and beta-cell trans-differentiation to alpha-cells. This amino acid sensing and signaling mechanism controls whole-body glucose homeostasis in mice and men.

AB - Zhang et al. generate and analyze inducible Rab1A knockout mice. The results reveal that Rab1A-mTORC1 mediates branched chain amino acids signaling and regulates PDX-dependent insulin transcription and beta-cell trans-differentiation to alpha-cells. This amino acid sensing and signaling mechanism controls whole-body glucose homeostasis in mice and men.

KW - PDX1

KW - Rab1A

KW - alpha-cell

KW - amino acids

KW - beta-cell

KW - diabetes

KW - glucose homeostasis

KW - insulin

KW - mTOR

KW - trans-differentiation

UR - https://www.scopus.com/pages/publications/85102534383

UR - https://www.scopus.com/pages/publications/85102534383#tab=citedBy

U2 - 10.1016/j.celrep.2021.108830

DO - 10.1016/j.celrep.2021.108830

M3 - Article

C2 - 33730578

SN - 2211-1247

VL - 34

JO - Cell Reports

JF - Cell Reports

IS - 11

M1 - 108830

ER -

Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis

Abstract

ASJC Scopus subject areas

Keywords

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