An Integrated Model of Action Selection

Distinct Modes of Cortical Control of Striatal Decision Making

Melissa J. Sharpe, Thomas Stalnaker, Nicolas W. Schuck, Simon Killcross, Geoffrey Schoenbaum, Yael Niv

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Making decisions in environments with few choice options is easy. We select the action that results in the most valued outcome. Making decisions in more complex environments, where the same action can produce different outcomes in different conditions, is much harder. In such circumstances, we propose that accurate action selection relies on top-down control from the prelimbic and orbitofrontal cortices over striatal activity through distinct thalamostriatal circuits. We suggest that the prelimbic cortex exerts direct influence over medium spiny neurons in the dorsomedial striatum to represent the state space relevant to the current environment. Conversely, the orbitofrontal cortex is argued to track a subject's position within that state space, likely through modulation of cholinergic interneurons.

Original languageEnglish (US)
Pages (from-to)53-76
Number of pages24
JournalAnnual review of psychology
Volume70
DOIs
StatePublished - Jan 4 2019

Fingerprint

Corpus Striatum
Decision Making
Prefrontal Cortex
Interneurons
Cholinergic Agents
Neurons

All Science Journal Classification (ASJC) codes

  • Psychology(all)

Cite this

Sharpe, Melissa J. ; Stalnaker, Thomas ; Schuck, Nicolas W. ; Killcross, Simon ; Schoenbaum, Geoffrey ; Niv, Yael. / An Integrated Model of Action Selection : Distinct Modes of Cortical Control of Striatal Decision Making. In: Annual review of psychology. 2019 ; Vol. 70. pp. 53-76.
@article{e781fd1416364dd4a28dc22e2fc1c00d,
title = "An Integrated Model of Action Selection: Distinct Modes of Cortical Control of Striatal Decision Making",
abstract = "Making decisions in environments with few choice options is easy. We select the action that results in the most valued outcome. Making decisions in more complex environments, where the same action can produce different outcomes in different conditions, is much harder. In such circumstances, we propose that accurate action selection relies on top-down control from the prelimbic and orbitofrontal cortices over striatal activity through distinct thalamostriatal circuits. We suggest that the prelimbic cortex exerts direct influence over medium spiny neurons in the dorsomedial striatum to represent the state space relevant to the current environment. Conversely, the orbitofrontal cortex is argued to track a subject's position within that state space, likely through modulation of cholinergic interneurons.",
author = "Sharpe, {Melissa J.} and Thomas Stalnaker and Schuck, {Nicolas W.} and Simon Killcross and Geoffrey Schoenbaum and Yael Niv",
year = "2019",
month = "1",
day = "4",
doi = "https://doi.org/10.1146/annurev-psych-010418-102824",
language = "English (US)",
volume = "70",
pages = "53--76",
journal = "Annual Review of Psychology",
issn = "0066-4308",
publisher = "Annual Reviews Inc.",

}

An Integrated Model of Action Selection : Distinct Modes of Cortical Control of Striatal Decision Making. / Sharpe, Melissa J.; Stalnaker, Thomas; Schuck, Nicolas W.; Killcross, Simon; Schoenbaum, Geoffrey; Niv, Yael.

In: Annual review of psychology, Vol. 70, 04.01.2019, p. 53-76.

Research output: Contribution to journalReview article

TY - JOUR

T1 - An Integrated Model of Action Selection

T2 - Distinct Modes of Cortical Control of Striatal Decision Making

AU - Sharpe, Melissa J.

AU - Stalnaker, Thomas

AU - Schuck, Nicolas W.

AU - Killcross, Simon

AU - Schoenbaum, Geoffrey

AU - Niv, Yael

PY - 2019/1/4

Y1 - 2019/1/4

N2 - Making decisions in environments with few choice options is easy. We select the action that results in the most valued outcome. Making decisions in more complex environments, where the same action can produce different outcomes in different conditions, is much harder. In such circumstances, we propose that accurate action selection relies on top-down control from the prelimbic and orbitofrontal cortices over striatal activity through distinct thalamostriatal circuits. We suggest that the prelimbic cortex exerts direct influence over medium spiny neurons in the dorsomedial striatum to represent the state space relevant to the current environment. Conversely, the orbitofrontal cortex is argued to track a subject's position within that state space, likely through modulation of cholinergic interneurons.

AB - Making decisions in environments with few choice options is easy. We select the action that results in the most valued outcome. Making decisions in more complex environments, where the same action can produce different outcomes in different conditions, is much harder. In such circumstances, we propose that accurate action selection relies on top-down control from the prelimbic and orbitofrontal cortices over striatal activity through distinct thalamostriatal circuits. We suggest that the prelimbic cortex exerts direct influence over medium spiny neurons in the dorsomedial striatum to represent the state space relevant to the current environment. Conversely, the orbitofrontal cortex is argued to track a subject's position within that state space, likely through modulation of cholinergic interneurons.

UR - http://www.scopus.com/inward/record.url?scp=85059495158&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059495158&partnerID=8YFLogxK

U2 - https://doi.org/10.1146/annurev-psych-010418-102824

DO - https://doi.org/10.1146/annurev-psych-010418-102824

M3 - Review article

VL - 70

SP - 53

EP - 76

JO - Annual Review of Psychology

JF - Annual Review of Psychology

SN - 0066-4308

ER -