Analysis microRNA-gene co-modules in glioblastoma multiforme based on integrative two types of genomic data

Jin Deng, Wei Kong, Huimin Wang, Shuaiqun Wang, Xiaoyang Mou

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Glioblastoma multiforme (GBM) is the most common primary central nervous system tumor. Although treatment continues to make progress in the past, the pathogenesis is still unknown to a large extent. MicroRNA (miRNA) is known to regulate cooperatively the expression of gene profiles in the post transcriptional stages and affect many crucial biological processes. The majority of the existing researches on GBM transcriptional regulation mechanism devoted to global analysis only on gene expression data, disregarding the complex coordination between miRNA and gene expression profiles. With the development of high throughput biotechnology and computational biology, it is possible to simulate and understand the regulatory role in cellular process by integrating gene expression profiles with miRNA data. In this article, we adopt the joint Non-negative Matrix Factorization Algorithm (JNMF) to integrate miRNA data and gene expression data to form co-modules. In addition, the characteristic co-modules and the number of miRNA related with GBM were identified by correlation analysis, thus constructing miRNA-gene regulation network to speculate the pathogenesis of GBM. The results demonstrated that the characteristic co-modules showed a significant biological correlation and potential association with GBM. Furthermore, GO biological processes and KEGG enrichment analysis further revealed the biological functions of miRNA targets gene in co-modules.

Original languageAmerican English
Title of host publication2018 2nd International Conference on Biomedical Engineering and Bioinformatics, ICBEB 2018
PublisherAssociation for Computing Machinery
ISBN (Electronic)9781450365062
DOIs
StatePublished - Sep 19 2018
Event2nd International Conference on Biomedical Engineering and Bioinformatics, ICBEB 2018 - Tianjin, China
Duration: Sep 19 2018Sep 21 2018

Publication series

NameACM International Conference Proceeding Series

Other

Other2nd International Conference on Biomedical Engineering and Bioinformatics, ICBEB 2018
Country/TerritoryChina
CityTianjin
Period9/19/189/21/18

ASJC Scopus subject areas

  • Software
  • Human-Computer Interaction
  • Computer Vision and Pattern Recognition
  • Computer Networks and Communications

Fingerprint

Dive into the research topics of 'Analysis microRNA-gene co-modules in glioblastoma multiforme based on integrative two types of genomic data'. Together they form a unique fingerprint.

Cite this