Abstract
Left ventricular (LV) function due to two concurrent ischaemic zones (IZs) is investigated using a cardiovascular system model. The model comprises a three-compartment LV, the venous return and the arterial system. Haemodynamic responses of the LV to changes in the IZ size and myocardial contraction timings are explored. Results show that the greater the degree of asynschonisation is between the normal zone and the IZ, and the larger the ischaemic size, the more severe the LV dysfunction. Pre-load augmentation improves LV function. Model-predicted features are consistent with reported observations associated with myocardial ischaemia. The extent of the usefulness and limitations of this model is also discussed.
| Original language | American English |
|---|---|
| Pages (from-to) | 477-480 |
| Number of pages | 4 |
| Journal | Medical and Biological Engineering and Computing |
| Volume | 34 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 1996 |
ASJC Scopus subject areas
- Biomedical Engineering
- Computer Science Applications
Keywords
- Asynchronous activation
- Dual ischaemic zones
- Pre-load augmentation
- Ventricular function