Analysis of factors associated with long-term (five or more years) cure in patients undergoing operation for Zollinger-Ellison syndrome

H. R. Alexander, D. L. Bartlett, D. J. Venzon, S. K. Libutti, J. L. Doppman, D. L. Fraker, J. A. Norton, F. Gibril, R. T. Jensen, B. Skogseid, M. L. Richards, N. W. Thompson

Research output: Contribution to journalArticle

Abstract

Background. Only 30% to 40% of patients with Zollinger-Ellison syndrome (ZES) undergoing operation with curative intent have biochemical cures. The purpose of this analysis was to identify perioperative factors associated with long-term (≥5 years) biochemical cures. Methods. From December 1981 to September 1997, 128 patients with potentially curable ZES underwent 152 abdominal explorations with resection of all identifiable disease. Of these, 31 outcomes were identified with documented cures at ≥5 years from operation and were compared with outcomes of 110 patients who were not cured. Univariate and multivariate statistical analyses were performed. Results. The results of a normal immediate postoperative fasting serum gastrin and secretin stimulation test were significantly and independently correlated with 50-year cure (P2 = .005 and .0099, respectively). A diagnosis of multiple endocrine neoplasia type 1 was significantly inversely correlated with cure on univariate analysis (P2 = .027). Gender, age, duration of symptoms, results of diagnostic tests, or results of imaging studies did not correlate with outcome. Conclusions. All patients with sporadic potentially curable ZES should undergo exploration because outcome is not associated with preoperative tests. Only 5% of patients with ZES and multiple endocrine neoplasia type 1 were cured at 5 years. A normal fasting serum gastrin or secretin stimulation value value immediately postoperatively provides important prognostic information.

Original languageEnglish (US)
Pages (from-to)1160-1166
Number of pages7
JournalSurgery
Volume124
Issue number6
DOIs
StatePublished - Jan 1 1998

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Zollinger-Ellison Syndrome
Statistical Factor Analysis
Multiple Endocrine Neoplasia Type 1
Secretin
Gastrins
Fasting
Serum
Routine Diagnostic Tests
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Alexander, H. R., Bartlett, D. L., Venzon, D. J., Libutti, S. K., Doppman, J. L., Fraker, D. L., ... Thompson, N. W. (1998). Analysis of factors associated with long-term (five or more years) cure in patients undergoing operation for Zollinger-Ellison syndrome. Surgery, 124(6), 1160-1166. https://doi.org/10.1067/msy.1998.92010
Alexander, H. R. ; Bartlett, D. L. ; Venzon, D. J. ; Libutti, S. K. ; Doppman, J. L. ; Fraker, D. L. ; Norton, J. A. ; Gibril, F. ; Jensen, R. T. ; Skogseid, B. ; Richards, M. L. ; Thompson, N. W. / Analysis of factors associated with long-term (five or more years) cure in patients undergoing operation for Zollinger-Ellison syndrome. In: Surgery. 1998 ; Vol. 124, No. 6. pp. 1160-1166.
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title = "Analysis of factors associated with long-term (five or more years) cure in patients undergoing operation for Zollinger-Ellison syndrome",
abstract = "Background. Only 30{\%} to 40{\%} of patients with Zollinger-Ellison syndrome (ZES) undergoing operation with curative intent have biochemical cures. The purpose of this analysis was to identify perioperative factors associated with long-term (≥5 years) biochemical cures. Methods. From December 1981 to September 1997, 128 patients with potentially curable ZES underwent 152 abdominal explorations with resection of all identifiable disease. Of these, 31 outcomes were identified with documented cures at ≥5 years from operation and were compared with outcomes of 110 patients who were not cured. Univariate and multivariate statistical analyses were performed. Results. The results of a normal immediate postoperative fasting serum gastrin and secretin stimulation test were significantly and independently correlated with 50-year cure (P2 = .005 and .0099, respectively). A diagnosis of multiple endocrine neoplasia type 1 was significantly inversely correlated with cure on univariate analysis (P2 = .027). Gender, age, duration of symptoms, results of diagnostic tests, or results of imaging studies did not correlate with outcome. Conclusions. All patients with sporadic potentially curable ZES should undergo exploration because outcome is not associated with preoperative tests. Only 5{\%} of patients with ZES and multiple endocrine neoplasia type 1 were cured at 5 years. A normal fasting serum gastrin or secretin stimulation value value immediately postoperatively provides important prognostic information.",
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Alexander, HR, Bartlett, DL, Venzon, DJ, Libutti, SK, Doppman, JL, Fraker, DL, Norton, JA, Gibril, F, Jensen, RT, Skogseid, B, Richards, ML & Thompson, NW 1998, 'Analysis of factors associated with long-term (five or more years) cure in patients undergoing operation for Zollinger-Ellison syndrome', Surgery, vol. 124, no. 6, pp. 1160-1166. https://doi.org/10.1067/msy.1998.92010

Analysis of factors associated with long-term (five or more years) cure in patients undergoing operation for Zollinger-Ellison syndrome. / Alexander, H. R.; Bartlett, D. L.; Venzon, D. J.; Libutti, S. K.; Doppman, J. L.; Fraker, D. L.; Norton, J. A.; Gibril, F.; Jensen, R. T.; Skogseid, B.; Richards, M. L.; Thompson, N. W.

In: Surgery, Vol. 124, No. 6, 01.01.1998, p. 1160-1166.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Analysis of factors associated with long-term (five or more years) cure in patients undergoing operation for Zollinger-Ellison syndrome

AU - Alexander, H. R.

AU - Bartlett, D. L.

AU - Venzon, D. J.

AU - Libutti, S. K.

AU - Doppman, J. L.

AU - Fraker, D. L.

AU - Norton, J. A.

AU - Gibril, F.

AU - Jensen, R. T.

AU - Skogseid, B.

AU - Richards, M. L.

AU - Thompson, N. W.

PY - 1998/1/1

Y1 - 1998/1/1

N2 - Background. Only 30% to 40% of patients with Zollinger-Ellison syndrome (ZES) undergoing operation with curative intent have biochemical cures. The purpose of this analysis was to identify perioperative factors associated with long-term (≥5 years) biochemical cures. Methods. From December 1981 to September 1997, 128 patients with potentially curable ZES underwent 152 abdominal explorations with resection of all identifiable disease. Of these, 31 outcomes were identified with documented cures at ≥5 years from operation and were compared with outcomes of 110 patients who were not cured. Univariate and multivariate statistical analyses were performed. Results. The results of a normal immediate postoperative fasting serum gastrin and secretin stimulation test were significantly and independently correlated with 50-year cure (P2 = .005 and .0099, respectively). A diagnosis of multiple endocrine neoplasia type 1 was significantly inversely correlated with cure on univariate analysis (P2 = .027). Gender, age, duration of symptoms, results of diagnostic tests, or results of imaging studies did not correlate with outcome. Conclusions. All patients with sporadic potentially curable ZES should undergo exploration because outcome is not associated with preoperative tests. Only 5% of patients with ZES and multiple endocrine neoplasia type 1 were cured at 5 years. A normal fasting serum gastrin or secretin stimulation value value immediately postoperatively provides important prognostic information.

AB - Background. Only 30% to 40% of patients with Zollinger-Ellison syndrome (ZES) undergoing operation with curative intent have biochemical cures. The purpose of this analysis was to identify perioperative factors associated with long-term (≥5 years) biochemical cures. Methods. From December 1981 to September 1997, 128 patients with potentially curable ZES underwent 152 abdominal explorations with resection of all identifiable disease. Of these, 31 outcomes were identified with documented cures at ≥5 years from operation and were compared with outcomes of 110 patients who were not cured. Univariate and multivariate statistical analyses were performed. Results. The results of a normal immediate postoperative fasting serum gastrin and secretin stimulation test were significantly and independently correlated with 50-year cure (P2 = .005 and .0099, respectively). A diagnosis of multiple endocrine neoplasia type 1 was significantly inversely correlated with cure on univariate analysis (P2 = .027). Gender, age, duration of symptoms, results of diagnostic tests, or results of imaging studies did not correlate with outcome. Conclusions. All patients with sporadic potentially curable ZES should undergo exploration because outcome is not associated with preoperative tests. Only 5% of patients with ZES and multiple endocrine neoplasia type 1 were cured at 5 years. A normal fasting serum gastrin or secretin stimulation value value immediately postoperatively provides important prognostic information.

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