Analytical aspects of population-specific DNA fingerprinting for individuals

Peter Smouse, C. Chevillon

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

An emerging problem of some interest is whether we can determine the population membership of a single individual, using a population-specific 'genetic fingerprint.' The levels of accuracy and precision required are beyond the reach of allozyme analysis, and attention has shifted to DNA polymorphisms. There are different types of DNA markers available for population surveys: RFLPs, mini- and microsatellites, and RAPDs, and each type has its own strengths and weaknesses. We present a generic analysis that relates gene pool separation to our ability to assign individuals, an analysis that does not depend on the type of marker. We then review strengths and weaknesses of different DNA markers, in the context of DNA fingerprinting. Codominant loci are best. It is possible to gain more information per marker with multlallelic loci, but diminishing returns set in rapidly, and it is better to add loci. A modest number of independent loci is best, each locus with a modest number of alleles and with each allele in modest frequency.

Original languageEnglish (US)
Pages (from-to)143-150
Number of pages8
JournalJournal of Heredity
Volume89
Issue number2
DOIs
StatePublished - Mar 1 1998

Fingerprint

DNA Fingerprinting
Genetic Markers
Alleles
Gene Pool
Minisatellite Repeats
Population Genetics
Dermatoglyphics
Restriction Fragment Length Polymorphisms
Microsatellite Repeats
Population
Isoenzymes
DNA
Surveys and Questionnaires

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Genetics
  • Molecular Biology
  • Biotechnology

Cite this

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Analytical aspects of population-specific DNA fingerprinting for individuals. / Smouse, Peter; Chevillon, C.

In: Journal of Heredity, Vol. 89, No. 2, 01.03.1998, p. 143-150.

Research output: Contribution to journalArticle

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