Anti-inflammatory property of the urinary metabolites of nobiletin in mouse

Shiming Li, Shengmin Sang, Min Hsiung Pan, Ching Shu Lai, Chih Yu Lo, Chung Yang, Chi-Tang Ho

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Nobiletin, a major component of polymethoxyflavones in citrus fruits, has a broad spectrum of health beneficial properties including anti-inflammatory and anti-carcinogenic activities. The metabolite identification of nobiletin in mouse urine has concluded that it undergoes mono-demethylation (3′- and 4′-demethylnobiletin) and di-demethylation (3′,4′-didemethylnobiletin) metabolic pathway. Biological screening of nobiletin and its metabolites has revealed that the metabolites possess more potent anti-inflammatory activity than their parent compound. Therefore, this letter reports the identification of nobiletin metabolites and their anti-inflammatory activity against LPS-induced NO production and iNOS, COX-2 protein expression in RAW264.7 macrophage.

Original languageEnglish (US)
Pages (from-to)5177-5181
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number18
DOIs
StatePublished - Sep 15 2007

Fingerprint

Metabolites
Anti-Inflammatory Agents
Citrus fruits
Citrus
Macrophages
Metabolic Networks and Pathways
Screening
Health
Urine
nobiletin
Proteins

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Molecular Medicine
  • Molecular Biology
  • Biochemistry
  • Clinical Biochemistry
  • Pharmaceutical Science
  • Organic Chemistry

Keywords

  • 3′,4′-Didemethylnobiletin
  • Anti-inflammatory activity
  • Demethylnobiletin
  • Nobiletin
  • Nobiletin metabolites

Cite this

Li, Shiming ; Sang, Shengmin ; Pan, Min Hsiung ; Lai, Ching Shu ; Lo, Chih Yu ; Yang, Chung ; Ho, Chi-Tang. / Anti-inflammatory property of the urinary metabolites of nobiletin in mouse. In: Bioorganic and Medicinal Chemistry Letters. 2007 ; Vol. 17, No. 18. pp. 5177-5181.
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Anti-inflammatory property of the urinary metabolites of nobiletin in mouse. / Li, Shiming; Sang, Shengmin; Pan, Min Hsiung; Lai, Ching Shu; Lo, Chih Yu; Yang, Chung; Ho, Chi-Tang.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 17, No. 18, 15.09.2007, p. 5177-5181.

Research output: Contribution to journalArticle

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T1 - Anti-inflammatory property of the urinary metabolites of nobiletin in mouse

AU - Li, Shiming

AU - Sang, Shengmin

AU - Pan, Min Hsiung

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AU - Lo, Chih Yu

AU - Yang, Chung

AU - Ho, Chi-Tang

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