Antibodies to sulfated glycolipids in Guillain-Barré syndrome

Amjad A. Illyas, Francis A. Mithen, Marinos C. Dalakas, Michelle Wargo, Zi Wei Chen, Leonard Bielory, Stuart D. Cook

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


Sera from 53 patients with acute Guillain-Barré syndrome (GBS), 15 patients with chronic inflammatory demyelinating polyneuropathy (CIDP), 13 patients with other neurological diseases (OND) and 31 healthy controls were tested for IgM and IgG antibodies to sulfoglucuronyl paragloboside (SGPG) and sulfatide by both an ELISA and a thin-layer chromatogram-overlay technique. Although the mean levels of anti-SGPG or anti-sulfatide antibodies in GBS patients were not elevated compared to controls, the occurrence of anti-SGPG antibodies was more frequent in GBS patients than in controls (P < 0.02). Acute GBS patients with antibodies to SGPG or sulfatide were clinically indistinguishable from other GBS patients. Our data suggest that elevated levels of antibodies to SGPG could be important in the pathogenesis of neuropathy in some GBS patients.

Original languageEnglish (US)
Pages (from-to)108-117
Number of pages10
JournalJournal of the Neurological Sciences
Issue number1
StatePublished - Sep 1991

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


  • Guillain-Barré syndrome
  • Immunoglobulins
  • Myelin-associated glycoprotein
  • Sulfatide
  • Sulfoglucuronyl glycolipids


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