Apium plants: Beyond simple food and phytopharmacological applications

Bahare Salehi, Alessandro Venditti, Claudio Frezza, Aysun Yücetepe, Ümit Altuntaş, Sibel Uluata, Monica Butnariu, Ioan Sarac, Shabnum Shaheen, Spyridon A. Petropoulos, Karl R. Matthews, Ceyda Sibel Kiliç, Maria Atanassova, Charles Oluwaseun Adetunji, Adedayo Oluwaseun Ademiluyi, Beraat Özçelik, Patrick Valere Tsouh Fokou, Natália Martins, William C. Cho, Javad Sharifi-Rad

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Apium plants belong to the Apiaceae family and are included among plants that have been in use in traditional medicine for thousands of years worldwide, including in the Mediterranean, as well as the tropical and subtropical regions of Asia and Africa. Some highlighted medical benefits include prevention of coronary and vascular diseases. Their phytochemical constituents consist of bergapten, flavonoids, glycosides, furanocoumarins, furocoumarin, limonene, psoralen, xanthotoxin, and selinene. Some of their pharmacological properties include anticancer, antioxidant, antimicrobial, antifungal, nematocidal, anti-rheumatism, antiasthma, anti-bronchitis, hepatoprotective, appetizer, anticonvulsant, antispasmodic, breast milk inducer, anti-jaundice, antihypertensive, anti-dysmenorrhea, prevention of cardiovascular diseases, and spermatogenesis induction. The present review summarizes data on ecology, botany, cultivation, habitat, medicinal use, phytochemical composition, preclinical and clinical pharmacological efficacy of Apium plants and provides future direction on how to take full advantage of Apium plants for the optimal benefit to mankind.

Original languageEnglish (US)
Article number3547
JournalApplied Sciences (Switzerland)
Issue number17
StatePublished - Sep 1 2019

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Instrumentation
  • Materials Science(all)
  • Fluid Flow and Transfer Processes
  • Process Chemistry and Technology
  • Computer Science Applications


  • Apium
  • Botany
  • Medicinal use
  • Pharmacological properties
  • Phytochemicals

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