Assessment of cumulative health risk in the World Trade Center general responder cohort

Ghalib A. Bello, Susan L. Teitelbaum, Roberto G. Lucchini, Christopher R. Dasaro, Moshe Shapiro, Julia R. Kaplan, Michael A. Crane, Denise J. Harrison, Benjamin J. Luft, Jacqueline M. Moline, Iris Udasin, Andrew C. Todd

Research output: Contribution to journalArticle

Abstract

Background: Multiple comorbidities have been reported among rescue/recovery workers responding to the 9/11/2001 WTC disaster. In this study, we developed an index that quantifies the cumulative physiological burden of comorbidities and predicts life expectancy in this cohort. Methods: A machine learning approach (gradient boosting) was used to model the relationship between mortality and several clinical parameters (laboratory test results, blood pressure, pulmonary function measures). This model was used to construct a risk index, which was validated by assessing its association with a number of health outcomes within the WTC general responder cohort. Results: The risk index showed significant associations with mortality, self-assessed physical health, and onset of multiple chronic conditions, particularly COPD, hypertension, asthma, and sleep apnea. Conclusion: As an aggregate of several clinical parameters, this index serves as a cumulative measure of physiological dysregulation and could be utilized as a prognostic indicator of life expectancy and morbidity risk.

Original languageEnglish (US)
Pages (from-to)63-76
Number of pages14
JournalAmerican journal of industrial medicine
Volume61
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Life Expectancy
Comorbidity
Health
Mortality
Sleep Apnea Syndromes
Disasters
Chronic Obstructive Pulmonary Disease
Asthma
Blood Pressure
Hypertension
Morbidity
Lung
Multiple Chronic Conditions
Machine Learning

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Keywords

  • 9/11
  • Health Risk Index
  • World Trade Center
  • mortality
  • physiological dysregulation

Cite this

Bello, G. A., Teitelbaum, S. L., Lucchini, R. G., Dasaro, C. R., Shapiro, M., Kaplan, J. R., ... Todd, A. C. (2018). Assessment of cumulative health risk in the World Trade Center general responder cohort. American journal of industrial medicine, 61(1), 63-76. https://doi.org/10.1002/ajim.22786
Bello, Ghalib A. ; Teitelbaum, Susan L. ; Lucchini, Roberto G. ; Dasaro, Christopher R. ; Shapiro, Moshe ; Kaplan, Julia R. ; Crane, Michael A. ; Harrison, Denise J. ; Luft, Benjamin J. ; Moline, Jacqueline M. ; Udasin, Iris ; Todd, Andrew C. / Assessment of cumulative health risk in the World Trade Center general responder cohort. In: American journal of industrial medicine. 2018 ; Vol. 61, No. 1. pp. 63-76.
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Bello, GA, Teitelbaum, SL, Lucchini, RG, Dasaro, CR, Shapiro, M, Kaplan, JR, Crane, MA, Harrison, DJ, Luft, BJ, Moline, JM, Udasin, I & Todd, AC 2018, 'Assessment of cumulative health risk in the World Trade Center general responder cohort', American journal of industrial medicine, vol. 61, no. 1, pp. 63-76. https://doi.org/10.1002/ajim.22786

Assessment of cumulative health risk in the World Trade Center general responder cohort. / Bello, Ghalib A.; Teitelbaum, Susan L.; Lucchini, Roberto G.; Dasaro, Christopher R.; Shapiro, Moshe; Kaplan, Julia R.; Crane, Michael A.; Harrison, Denise J.; Luft, Benjamin J.; Moline, Jacqueline M.; Udasin, Iris; Todd, Andrew C.

In: American journal of industrial medicine, Vol. 61, No. 1, 01.01.2018, p. 63-76.

Research output: Contribution to journalArticle

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AU - Harrison, Denise J.

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AU - Udasin, Iris

AU - Todd, Andrew C.

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