Association between polymorphisms in FOXP3 and EBI3 genes and the risk for development of allergic rhinitis in Chinese subjects

Yuan Zhang, Su Duan, Xin Wei, Yanming Zhao, Liping Zhao, Luo Zhang

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Objective: To investigate whether polymorphisms in forkhead box protein 3 (FOXP3) and EBV-induced gene 3 (EBI3) genes are associated with allergic rhinitis (AR) in Chinese patients. Methods: A population-based case-control association study design was used to assess the risk of AR conferred by single nucleotide polymorphism. s (SNPs) in FOXP3 and EBI3 gene regions. DNA was extracted from 378 patients with AR and 330 healthy controls and analyzed for selected and tagged SNPs. Overall, 9 SNPs were selected and genotyped. Results: In the single-locus analyses of AR risk, the allele frequencies of rs428253 in EBI3 gene were significantly different between the AR patients and control subjects (p=1.00E-04); even after 10,000 permutations (P<0.05). Logistic regression analyses, adjusted for age and gender, further showed a significant association between EBI3 rs428253 and protective effects against AR (p=0.015, OR = 0.624 for CG/CC). The diplotype rs3761548-rs4824747 in FOXP3 gene with "AG" was associated with risk of AR (p=0.031, OR = 1.755). Conclusions: The findings of this study support the potential role of regulatory T cells and genetic variations in the regions around FOXP3 and EBI3 genes in modifying the risk for AR development in Chinese patients.

Original languageEnglish (US)
Pages (from-to)939-945
Number of pages7
JournalHuman Immunology
Volume73
Issue number9
DOIs
StatePublished - Sep 1 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Association between polymorphisms in FOXP3 and EBI3 genes and the risk for development of allergic rhinitis in Chinese subjects'. Together they form a unique fingerprint.

  • Cite this