Association of air pollution sources and aldehydes with biomarkers of blood coagulation, pulmonary inflammation, and systemic oxidative stress

Brent Altemose; Mark G. Robson; Howard M. Kipen; Pamela Ohman Strickland; Qingyu Meng; Jicheng Gong; Wei Huang; Guangfa Wang; David Q. Rich; Tong Zhu; Junfeng Zhang

doi:https://doi.org/10.1038/jes.2016.38

Association of air pollution sources and aldehydes with biomarkers of blood coagulation, pulmonary inflammation, and systemic oxidative stress

Brent Altemose, Mark G. Robson, Howard M. Kipen, Pamela Ohman Strickland, Qingyu Meng, Jicheng Gong, Wei Huang, Guangfa Wang, David Q. Rich, Tong Zhu, Junfeng Zhang

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Using data collected before, during, and after the 2008 Summer Olympic Games in Beijing, this study examines associations between biomarkers of blood coagulation (VWF, sCD62P and sCD40L), pulmonary inflammation (EBC pH, EBC nitrite, and eNO), and systemic oxidative stress (urinary 8-OHdG) with sources of air pollution identified utilizing principal component analysis and with concentrations of three aldehydes of health concern. Associations between the biomarkers and the air pollution source types and aldehydes were examined using a linear mixed effects model, regressing through seven lag days and controlling for ambient temperature, relative humidity, gender, and day of week for the biomarker measurements. The biomarkers for pulmonary inflammation, particularly EBC pH and eNO, were most consistently associated with vehicle and industrial combustion, oil combustion, and vegetative burning. The biomarkers for blood coagulation, particularly VWF and sCD62p, were most consistently associated with oil combustion. Systemic oxidative stress biomarker (8-OHdG) was most consistently associated with vehicle and industrial combustion. The associations of the biomarkers were generally not significant or consistent with secondary formation of pollutants and with the aldehydes. The findings support policies to control anthropogenic pollution sources rather than natural soil or road dust from a cardio-respiratory health standpoint.

Original language	English (US)
Pages (from-to)	244-250
Number of pages	7
Journal	Journal of Exposure Science and Environmental Epidemiology
Volume	27
Issue number	3
DOIs	https://doi.org/10.1038/jes.2016.38
State	Published - May 1 2017

ASJC Scopus subject areas

Epidemiology
Toxicology
Pollution
Public Health, Environmental and Occupational Health

Keywords

Air pollution
Aldehydes
Cardiorespiratory biomarkers
Olympics
Pollutant sources
Principal component analysis

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https://doi.org/10.1038/jes.2016.38

Cite this

Altemose, B., Robson, M. G., Kipen, H. M., Strickland, P. O., Meng, Q., Gong, J., Huang, W., Wang, G., Rich, D. Q., Zhu, T., & Zhang, J. (2017). Association of air pollution sources and aldehydes with biomarkers of blood coagulation, pulmonary inflammation, and systemic oxidative stress. Journal of Exposure Science and Environmental Epidemiology, 27(3), 244-250. https://doi.org/10.1038/jes.2016.38

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title = "Association of air pollution sources and aldehydes with biomarkers of blood coagulation, pulmonary inflammation, and systemic oxidative stress",

abstract = "Using data collected before, during, and after the 2008 Summer Olympic Games in Beijing, this study examines associations between biomarkers of blood coagulation (VWF, sCD62P and sCD40L), pulmonary inflammation (EBC pH, EBC nitrite, and eNO), and systemic oxidative stress (urinary 8-OHdG) with sources of air pollution identified utilizing principal component analysis and with concentrations of three aldehydes of health concern. Associations between the biomarkers and the air pollution source types and aldehydes were examined using a linear mixed effects model, regressing through seven lag days and controlling for ambient temperature, relative humidity, gender, and day of week for the biomarker measurements. The biomarkers for pulmonary inflammation, particularly EBC pH and eNO, were most consistently associated with vehicle and industrial combustion, oil combustion, and vegetative burning. The biomarkers for blood coagulation, particularly VWF and sCD62p, were most consistently associated with oil combustion. Systemic oxidative stress biomarker (8-OHdG) was most consistently associated with vehicle and industrial combustion. The associations of the biomarkers were generally not significant or consistent with secondary formation of pollutants and with the aldehydes. The findings support policies to control anthropogenic pollution sources rather than natural soil or road dust from a cardio-respiratory health standpoint.",

keywords = "Air pollution, Aldehydes, Cardiorespiratory biomarkers, Olympics, Pollutant sources, Principal component analysis",

author = "Brent Altemose and Robson, {Mark G.} and Kipen, {Howard M.} and Strickland, {Pamela Ohman} and Qingyu Meng and Jicheng Gong and Wei Huang and Guangfa Wang and Rich, {David Q.} and Tong Zhu and Junfeng Zhang",

note = "Funding Information: We thank the HEART study team for their effort in sample and data collection and previous data analyses. The HEART study was originally funded in part by a grant from HEI (#4760-RPFA05-3) and a grant from NIEHS (#1R01 ES0158640), as well NIEHS P30 Center Grant ES005022. Dr. Zhu was partly funded by Beijing EPA (OITCG08026056). However, the opinions expressed in this manuscript are solely of the authors and do not necessarily reflects those of the funding agencies. Publisher Copyright: {\textcopyright} 2017 Nature America, Inc., part of Springer Nature. All rights reserved.",

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Altemose, B, Robson, MG , Kipen, HM , Strickland, PO, Meng, Q, Gong, J, Huang, W, Wang, G, Rich, DQ, Zhu, T & Zhang, J 2017, 'Association of air pollution sources and aldehydes with biomarkers of blood coagulation, pulmonary inflammation, and systemic oxidative stress', Journal of Exposure Science and Environmental Epidemiology, vol. 27, no. 3, pp. 244-250. https://doi.org/10.1038/jes.2016.38

Association of air pollution sources and aldehydes with biomarkers of blood coagulation, pulmonary inflammation, and systemic oxidative stress. / Altemose, Brent; Robson, Mark G.; Kipen, Howard M. et al.

In: Journal of Exposure Science and Environmental Epidemiology, Vol. 27, No. 3, 01.05.2017, p. 244-250.

Research output: Contribution to journal › Article › peer-review

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AU - Altemose, Brent

AU - Robson, Mark G.

AU - Kipen, Howard M.

AU - Strickland, Pamela Ohman

AU - Meng, Qingyu

AU - Gong, Jicheng

AU - Huang, Wei

AU - Wang, Guangfa

AU - Rich, David Q.

AU - Zhu, Tong

AU - Zhang, Junfeng

N1 - Funding Information: We thank the HEART study team for their effort in sample and data collection and previous data analyses. The HEART study was originally funded in part by a grant from HEI (#4760-RPFA05-3) and a grant from NIEHS (#1R01 ES0158640), as well NIEHS P30 Center Grant ES005022. Dr. Zhu was partly funded by Beijing EPA (OITCG08026056). However, the opinions expressed in this manuscript are solely of the authors and do not necessarily reflects those of the funding agencies. Publisher Copyright: © 2017 Nature America, Inc., part of Springer Nature. All rights reserved.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Using data collected before, during, and after the 2008 Summer Olympic Games in Beijing, this study examines associations between biomarkers of blood coagulation (VWF, sCD62P and sCD40L), pulmonary inflammation (EBC pH, EBC nitrite, and eNO), and systemic oxidative stress (urinary 8-OHdG) with sources of air pollution identified utilizing principal component analysis and with concentrations of three aldehydes of health concern. Associations between the biomarkers and the air pollution source types and aldehydes were examined using a linear mixed effects model, regressing through seven lag days and controlling for ambient temperature, relative humidity, gender, and day of week for the biomarker measurements. The biomarkers for pulmonary inflammation, particularly EBC pH and eNO, were most consistently associated with vehicle and industrial combustion, oil combustion, and vegetative burning. The biomarkers for blood coagulation, particularly VWF and sCD62p, were most consistently associated with oil combustion. Systemic oxidative stress biomarker (8-OHdG) was most consistently associated with vehicle and industrial combustion. The associations of the biomarkers were generally not significant or consistent with secondary formation of pollutants and with the aldehydes. The findings support policies to control anthropogenic pollution sources rather than natural soil or road dust from a cardio-respiratory health standpoint.

AB - Using data collected before, during, and after the 2008 Summer Olympic Games in Beijing, this study examines associations between biomarkers of blood coagulation (VWF, sCD62P and sCD40L), pulmonary inflammation (EBC pH, EBC nitrite, and eNO), and systemic oxidative stress (urinary 8-OHdG) with sources of air pollution identified utilizing principal component analysis and with concentrations of three aldehydes of health concern. Associations between the biomarkers and the air pollution source types and aldehydes were examined using a linear mixed effects model, regressing through seven lag days and controlling for ambient temperature, relative humidity, gender, and day of week for the biomarker measurements. The biomarkers for pulmonary inflammation, particularly EBC pH and eNO, were most consistently associated with vehicle and industrial combustion, oil combustion, and vegetative burning. The biomarkers for blood coagulation, particularly VWF and sCD62p, were most consistently associated with oil combustion. Systemic oxidative stress biomarker (8-OHdG) was most consistently associated with vehicle and industrial combustion. The associations of the biomarkers were generally not significant or consistent with secondary formation of pollutants and with the aldehydes. The findings support policies to control anthropogenic pollution sources rather than natural soil or road dust from a cardio-respiratory health standpoint.

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KW - Aldehydes

KW - Cardiorespiratory biomarkers

KW - Olympics

KW - Pollutant sources

KW - Principal component analysis

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Association of air pollution sources and aldehydes with biomarkers of blood coagulation, pulmonary inflammation, and systemic oxidative stress

Abstract

ASJC Scopus subject areas

Keywords

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