@article{724ff9c441e3427c843b5b92d2499968,
title = "Association of htlv-iii with epstein-barr virus infection and abnormalities of t lymphocytes in homosexual men",
abstract = "Homosexual men were studied for associations among human T-lymphotropic virus type III (HTLV-III) infection, Epstein-Barr virus (EBV) infection, and T cell abnormalities. The presence of IgG antibody to EBV capsid antigen and antibody to EBV early antigen was significantly associated with augmented counts of suppressor T cells in healthy HTLV- III-seronegative men. HTLV-III-seropositive asymptomatic subjects had significantly enhanced titers of antibody to EBV and lower ratios of helper to suppressor T cells compared with HTLV-III-seronegative homosexual men. Of three men who seroconverted to HTLV-III, two had a greater than fourfold increase in titer of IgG antibody to EBV capsid antigen after seroconversion. These results suggest that the interaction of HTLV- III and EBV and their immunologic perturbations are significant in the natural history of this retrovirus infection in homosexual men.",
author = "Rinaldo, {Charles R.} and Kingsley, {Lawrence A.} and Lyter, {David W.} and Rabin, {Bruce S.} and Atchison, {Robert W.} and Bodner, {Anne J.} and Weiss, {Stanley H.} and Saxinger, {W. Carl} and Rinaldo, {Charles R.} and Kingsley, {Lawrence A.} and Lyter, {David W.} and Rabin, {Bruce S.} and Atchison, {Robert W.} and Bodner, {Anne J.} and Weiss, {Stanley H.} and Saxinger, {W. Carl} and Rinaldo, {Charles R.} and Kingsley, {Lawrence A.} and Lyter, {David W.} and Rabin, {Bruce S.} and Atchison, {Robert W.} and Bodner, {Anne J.} and Weiss, {Stanley H.} and Saxinger, {W. Carl} and Rinaldo, {Charles R.} and Kingsley, {Lawrence A.} and Lyter, {David W.} and Rabin, {Bruce S.} and Atchison, {Robert W.} and Bodner, {Anne J.} and Weiss, {Stanley H.} and Saxinger, {W. Carl} and Rinaldo, {Charles R.} and Kingsley, {Lawrence A.} and Lyter, {David W.} and Rabin, {Bruce S.} and Atchison, {Robert W.} and Bodner, {Anne J.} and Weiss, {Stanley H.} and Saxinger, {W. Carl}",
note = "Funding Information: Received for publication 11 December 1985,and in revised form 8 April 1986. Informed consent was obtained from the participants in this study in accordance with the guidelines of the U.S. Department of Health and Human Services and the participating institutions. This work was supported in part by grant AI-16212 from the National Institutes of Health, contracts NOI-CP-21007,NOl-CM-37609, and YOl-CP-00502 from the National Cancer Institute, and funds from the Pathology Education Research Foundation, University of Pittsburgh. We thank Drs. R. Gallo, W. Blattner, R. Biggar, S. Fisher, and M. Ho for discussions and cooperation and R. DeBiasio, Dr. J. Zhao, Dr. T. Lin, Dr. M. Breinig, M. Hoh, F. Laurent, E. MerraIl, M. Griffin, L. Youngblood, M. Lassak, and J. Fossati for assistance. Please address requests for reprints to Dr. Charles R. Rinaldo, Jr., Department of Infectious Diseases and Microbiology, A417 Crabtree Hall, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15261.",
year = "1986",
month = oct,
doi = "10.1093/infdis/154.4.556",
language = "American English",
volume = "154",
pages = "556--561",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "4",
}