Association of serum albumin with markers of nutritional status among HIV-infected and uninfected rwandan women

Jean Claude Dusingize, Donald R. Hoover, Qiuhu Shi, Eugene Mutimura, Elizabeth Kiefer, Mardge Cohen, Kathryn Anastos

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Introduction: The objectives of this study are to address if and how albumin can be used as an indication of malnutrition in HIV infected and uninfected Africans. Methods: In 2005, 710 HIV-infected and 226 HIV-uninfected women enrolled in a cohort study. Clinical/demographic parameters, CD4 count, albumin, liver transaminases; anthropometric measurements and Bioelectrical Impedance Analysis (BIA) were performed. Malnutrition outcomes were defined as body mass index (BMI), Fat-free mass index (FFMI) and Fat mass index (FMI). Separate linear predictive models including albumin were fit to these outcomes in HIV negative and HIV positive women by CD4 strata (CD4>350,200-350 and <200 cells/μl). Results: In unadjusted models for each outcome in HIV-negative and HIV positive women with CD4>350 cells/μl, serum albumin was not significantly associated with BMI, FFMI or FMI. Albumin was significantly associated with all three outcomes (p<0.05) in HIV+ women with CD4 200-350 cells/μl, and highly significant in HIV+ women with CD4<200 cells/μl (P<0.001). In multivariable linear regression, albumin remained associated with FFMI in women with CD4 count<200 cells/μl (p<0.01) but not in HIV+ women with CD4>200. Discussion: While serum albumin is widely used to indicate nutritional status it did not consistently predict malnutrition outcomes in HIV- women or HIV+ women with higher CD4. This result suggests that albumin may measure end stage disease as well as malnutrition and should not be used as a proxy for nutritional status without further study of its association with validated measures.

Original languageEnglish (US)
Article numbere35079
JournalPLoS ONE
Volume7
Issue number4
DOIs
StatePublished - Apr 19 2012

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Nutritional Status
Serum Albumin
HIV
Albumins
Malnutrition
Fats
Body Mass Index
Proxy
CD4 Lymphocyte Count
Transaminases
Electric Impedance
Linear Models
Cohort Studies
Demography
Liver

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • General
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Dusingize, Jean Claude ; Hoover, Donald R. ; Shi, Qiuhu ; Mutimura, Eugene ; Kiefer, Elizabeth ; Cohen, Mardge ; Anastos, Kathryn. / Association of serum albumin with markers of nutritional status among HIV-infected and uninfected rwandan women. In: PLoS ONE. 2012 ; Vol. 7, No. 4.
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Association of serum albumin with markers of nutritional status among HIV-infected and uninfected rwandan women. / Dusingize, Jean Claude; Hoover, Donald R.; Shi, Qiuhu; Mutimura, Eugene; Kiefer, Elizabeth; Cohen, Mardge; Anastos, Kathryn.

In: PLoS ONE, Vol. 7, No. 4, e35079, 19.04.2012.

Research output: Contribution to journalArticle

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T1 - Association of serum albumin with markers of nutritional status among HIV-infected and uninfected rwandan women

AU - Dusingize, Jean Claude

AU - Hoover, Donald R.

AU - Shi, Qiuhu

AU - Mutimura, Eugene

AU - Kiefer, Elizabeth

AU - Cohen, Mardge

AU - Anastos, Kathryn

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