Associations Between Neurocognitive Impairment and Biomarkers of Poor Physiologic Reserve in a Clinic-Based Sample of Older Adults Living with HIV

Kalvin C. Yu, Paul A. D'Avanzo, Leigh Nesheiwat, Richard E. Greene, Antonio Urbina, Perry N. Halkitis, Farzana Kapadia

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Data from a cross-sectional study of a clinic-based sample of older people living with HIV (PLWH; n = 100) were used to examine associations between biomarkers of physical health and neurocognitive impairment (NCI). In this sample, anemia, chronic kidney disease (CKD) stages 4-5, and hypocalcemia were associated with impairment in executive functioning or processing speed. Furthermore, participants with anemia were more likely to have CD4+ T cell counts <200 cells/mm32 [1] = 19.57, p < .001); hypocalcemia (χ2 [1] = 17.55, p < .001); and CKD 4-5 (χ2 [2] = 10.12, p = .006). Black and Hispanic participants were more likely to be anemic compared to other races and ethnicities (χ2 [3] = 12.76, p = .005). Common medical conditions (e.g., anemia, hypocalcemia, CKD) should be investigated as potential contributors to NCI in older PLWH. Additionally, laboratory testing in racial/ethnic minority PLWH may help inform NCI screening.

Original languageEnglish (US)
Pages (from-to)55-66
Number of pages12
JournalJournal of the Association of Nurses in AIDS Care
Volume28
Issue number1
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Advanced and Specialized Nursing

Keywords

  • HIV
  • neurocognitive impairment
  • screening

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