Asymmetry between Activators and Deactivators in Functional Protein Networks

Ammar Tareen, Ned S. Wingreen, Ranjan Mukhopadhyay

Research output: Contribution to journalArticlepeer-review


Are “turn-on” and “turn-off” functions in protein-protein interaction networks exact opposites of each other? To answer this question, we implement a minimal model for the evolution of functional protein-interaction networks using a sequence-based mutational algorithm, and apply the model to study neutral drift in networks that yield oscillatory dynamics. We study the roles of activators and deactivators, two core components of oscillatory protein interaction networks, and find a striking asymmetry in the roles of activating and deactivating proteins, where activating proteins tend to be synergistic and deactivating proteins tend to be competitive.

Original languageAmerican English
Article number10131
JournalScientific reports
Issue number1
StatePublished - Dec 1 2020

ASJC Scopus subject areas

  • General


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