Autoregulated pulsed-DC mode iontophoretic transdermal system

C. Carley, S. Wolpert, John Li

Research output: Contribution to conferencePaper

Abstract

An autoregulated pulsed-DC iontophoretic device with slow turn-on current has been developed. A specialized high-frequency pulse with a duty cycle of 50% or less is used which will reduce skin irritation due to polarization effects. To avoid patient discomfort, current delivery is increased gradually over a two-minute period to allow the skin to adapt to the applied current level. The rate of drug delivery is regulated by controlling the energy of the delivered pulse. For antihypertensive-drug administration, the device has the arterial pressure and continually readjusts delivery rates to keep it close to a desired target value.

Original languageEnglish (US)
Pages51-52
Number of pages2
StatePublished - Dec 1 1989
EventProceedings of the Fifteenth Annual Northeast Bioengineering Conference - Boston, MA, USA
Duration: Mar 27 1989Mar 28 1989

Other

OtherProceedings of the Fifteenth Annual Northeast Bioengineering Conference
CityBoston, MA, USA
Period3/27/893/28/89

Fingerprint

Skin
Drug delivery
Antihypertensive Agents
Polarization

All Science Journal Classification (ASJC) codes

  • Bioengineering

Cite this

Carley, C., Wolpert, S., & Li, J. (1989). Autoregulated pulsed-DC mode iontophoretic transdermal system. 51-52. Paper presented at Proceedings of the Fifteenth Annual Northeast Bioengineering Conference, Boston, MA, USA, .
Carley, C. ; Wolpert, S. ; Li, John. / Autoregulated pulsed-DC mode iontophoretic transdermal system. Paper presented at Proceedings of the Fifteenth Annual Northeast Bioengineering Conference, Boston, MA, USA, .2 p.
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Carley, C, Wolpert, S & Li, J 1989, 'Autoregulated pulsed-DC mode iontophoretic transdermal system' Paper presented at Proceedings of the Fifteenth Annual Northeast Bioengineering Conference, Boston, MA, USA, 3/27/89 - 3/28/89, pp. 51-52.

Autoregulated pulsed-DC mode iontophoretic transdermal system. / Carley, C.; Wolpert, S.; Li, John.

1989. 51-52 Paper presented at Proceedings of the Fifteenth Annual Northeast Bioengineering Conference, Boston, MA, USA, .

Research output: Contribution to conferencePaper

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Carley C, Wolpert S, Li J. Autoregulated pulsed-DC mode iontophoretic transdermal system. 1989. Paper presented at Proceedings of the Fifteenth Annual Northeast Bioengineering Conference, Boston, MA, USA, .