Autoshaping of chlordiazepoxide drinking in non-deprived rats

Arthur Tomie, Lauren E. Wong, Larissa A. Pohorecky

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Effects of autoshaping procedures (Paired versus Random) and sipper fluid [chlordiazepoxide (CDP) versus water] on sipper-directed drinking were evaluated in 32 male Long-Evans rats maintained with free access to food and water. For the Paired/CDP group (n = 16), autoshaping procedures consisted of the presentation of the CDP sipper conditioned stimulus (CS) followed by the response-independent presentation of the food unconditioned stimulus (US). The concentration of CDP in the sipper CS (0.05, 0.10, 0.15, 0.20, and 0.25 mg/ml CDP) was increased across sessions. The Paired/Water group (n = 8) received only water in the sipper CS. The Random/CDP group (n = 8) received the CDP sipper CS and food US randomly with respect to one another. The Paired/CDP group drank significantly more of the 0.20 mg/ml and 0.25 mg/ml CDP solutions than the Random/CDP control, and more fluid than the Paired/Water control group when the sipper CS for the Paired/CDP group contained the three highest concentrations of CDP. CS-Only extinction procedures reliably reduced sipper CS-directed drinking in the Paired/CDP and the Paired/Water groups, but not in the Random/CDP group. Data are consistent with the hypothesis that Pavlovian autoshaping procedures induce sipper CS-directed drinking of CDP in rats deprived of neither food nor fluid. Implications for the autoshaping model of drug abuse are discussed.

Original languageEnglish (US)
Pages (from-to)273-281
Number of pages9
JournalBehavioural Brain Research
Issue number2
StatePublished - Feb 28 2005

ASJC Scopus subject areas

  • Behavioral Neuroscience


  • Autoshaping
  • Chlordiazepoxide
  • Extinction
  • Pavlovian
  • Pseudoconditioning
  • Rats


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