Autosis: A New Target to Prevent Cell Death

Jihoon Nah, Daniela Zablocki, Junichi Sadoshima

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Excessive autophagy induces a defined form of cell death called autosis, which is characterized by unique morphological features, including ballooning of perinuclear space and biochemical features, including sensitivity to cardiac glycosides. Autosis is observed during the late phase of reperfusion after a period of ischemia and contributes to myocardial injury. This review discusses unique features of autosis, the involvement of autosis in myocardial injury, and the molecular mechanism of autosis. Because autosis promotes myocardial injury under some conditions, a better understanding of autosis may lead to development of novel interventions to protect the heart against myocardial stress.

Original languageEnglish (US)
Pages (from-to)857-869
Number of pages13
JournalJACC: Basic to Translational Science
Volume5
Issue number8
DOIs
StatePublished - Aug 2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Keywords

  • Na,K–adenosine triphosphatase
  • autophagic cell death
  • autophagic flux
  • autosis
  • beclin 1
  • rubicon

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