Bacteremia due to Mycobacterium tuberculosis or M. bovis, bacille Camette-Guérin (BCG) among HIV-positive children and adults in Zambia

Richard D. Waddell, Kennedy Lishimpi, C. Fordham Von Reyn, Chifumbe Chintu, K. S. Baboo, Barry Kreiswirth, Elizabeth A. Talbot, Margaret R. Karagas

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Background: Among adults with advanced HIV infection in developing countries, bacteremia due to Mycobacterium tuberculosis (MTB) is common and bacteremia due to M. bovis (bacille Calmette-Guérin; BCG) is rare. Comparable data are not available for children with HIV. Objective: To compare the prevalence of bacteremia due to M. tuberculosis or M. bovis BCG in hospitalized children and adults with HIV infection in a developing country with a high prevalence of tuberculosis and HIV and > 95% BCG immunization coverage. Design: Descriptive cross-sectional study. Methods: Prospectively hospitalized patients in Lusaka, Zambia who were suspected to have HIV infection underwent phlebotomy for HIV ELISA, HIV viral load, and lysiscentrifugation blood culture for mycobacteria. Histories were obtained and patients were examined for BCG scars. Mycobacterial isolates were identified using DNA probes for MTB complex (MTBC), multiplex PCR and IS6110 typing. Results: The median age of 387 HIV-positive children was 15 months; 98% were BCG immunized. The median age of 344 HIV-positive adults was 32 years; 44% were BCG immunized. Blood cultures were positive for mycobacteria in six children (2%) and 38 adults(11%) (P < 0.001). The six pediatric isolates included five MTBC (40% clustered) and one BCG. The 38 adult isolates included 36 MTBC (16% clustered) and two M. avium complex. Conclusion: Bacteremia due to MTB is less common among children than adults with advanced HIV infection in Zambia. Bacteremia due to M. bovis BCG is rare even among children with recent BCG immunization and symptomatic HIV infection.

Original languageEnglish (US)
Pages (from-to)55-60
Number of pages6
JournalAIDS
Volume15
Issue number1
DOIs
StatePublished - Jan 5 2001
Externally publishedYes

Fingerprint

Zambia
Bacteremia
Mycobacterium tuberculosis
HIV Infections
HIV
Mycobacterium
Developing Countries
Immunization
Hospitalized Child
Phlebotomy
Multiplex Polymerase Chain Reaction
DNA Probes
Viral Load
Cicatrix
Tuberculosis
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Pediatrics

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Immunology and Allergy
  • Immunology

Keywords

  • BCG
  • Bacille Calmette-Guérin
  • HIV
  • Tuberculosis
  • Zambia

Cite this

Waddell, Richard D. ; Lishimpi, Kennedy ; Von Reyn, C. Fordham ; Chintu, Chifumbe ; Baboo, K. S. ; Kreiswirth, Barry ; Talbot, Elizabeth A. ; Karagas, Margaret R. / Bacteremia due to Mycobacterium tuberculosis or M. bovis, bacille Camette-Guérin (BCG) among HIV-positive children and adults in Zambia. In: AIDS. 2001 ; Vol. 15, No. 1. pp. 55-60.
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title = "Bacteremia due to Mycobacterium tuberculosis or M. bovis, bacille Camette-Gu{\'e}rin (BCG) among HIV-positive children and adults in Zambia",
abstract = "Background: Among adults with advanced HIV infection in developing countries, bacteremia due to Mycobacterium tuberculosis (MTB) is common and bacteremia due to M. bovis (bacille Calmette-Gu{\'e}rin; BCG) is rare. Comparable data are not available for children with HIV. Objective: To compare the prevalence of bacteremia due to M. tuberculosis or M. bovis BCG in hospitalized children and adults with HIV infection in a developing country with a high prevalence of tuberculosis and HIV and > 95{\%} BCG immunization coverage. Design: Descriptive cross-sectional study. Methods: Prospectively hospitalized patients in Lusaka, Zambia who were suspected to have HIV infection underwent phlebotomy for HIV ELISA, HIV viral load, and lysiscentrifugation blood culture for mycobacteria. Histories were obtained and patients were examined for BCG scars. Mycobacterial isolates were identified using DNA probes for MTB complex (MTBC), multiplex PCR and IS6110 typing. Results: The median age of 387 HIV-positive children was 15 months; 98{\%} were BCG immunized. The median age of 344 HIV-positive adults was 32 years; 44{\%} were BCG immunized. Blood cultures were positive for mycobacteria in six children (2{\%}) and 38 adults(11{\%}) (P < 0.001). The six pediatric isolates included five MTBC (40{\%} clustered) and one BCG. The 38 adult isolates included 36 MTBC (16{\%} clustered) and two M. avium complex. Conclusion: Bacteremia due to MTB is less common among children than adults with advanced HIV infection in Zambia. Bacteremia due to M. bovis BCG is rare even among children with recent BCG immunization and symptomatic HIV infection.",
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Bacteremia due to Mycobacterium tuberculosis or M. bovis, bacille Camette-Guérin (BCG) among HIV-positive children and adults in Zambia. / Waddell, Richard D.; Lishimpi, Kennedy; Von Reyn, C. Fordham; Chintu, Chifumbe; Baboo, K. S.; Kreiswirth, Barry; Talbot, Elizabeth A.; Karagas, Margaret R.

In: AIDS, Vol. 15, No. 1, 05.01.2001, p. 55-60.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Bacteremia due to Mycobacterium tuberculosis or M. bovis, bacille Camette-Guérin (BCG) among HIV-positive children and adults in Zambia

AU - Waddell, Richard D.

AU - Lishimpi, Kennedy

AU - Von Reyn, C. Fordham

AU - Chintu, Chifumbe

AU - Baboo, K. S.

AU - Kreiswirth, Barry

AU - Talbot, Elizabeth A.

AU - Karagas, Margaret R.

PY - 2001/1/5

Y1 - 2001/1/5

N2 - Background: Among adults with advanced HIV infection in developing countries, bacteremia due to Mycobacterium tuberculosis (MTB) is common and bacteremia due to M. bovis (bacille Calmette-Guérin; BCG) is rare. Comparable data are not available for children with HIV. Objective: To compare the prevalence of bacteremia due to M. tuberculosis or M. bovis BCG in hospitalized children and adults with HIV infection in a developing country with a high prevalence of tuberculosis and HIV and > 95% BCG immunization coverage. Design: Descriptive cross-sectional study. Methods: Prospectively hospitalized patients in Lusaka, Zambia who were suspected to have HIV infection underwent phlebotomy for HIV ELISA, HIV viral load, and lysiscentrifugation blood culture for mycobacteria. Histories were obtained and patients were examined for BCG scars. Mycobacterial isolates were identified using DNA probes for MTB complex (MTBC), multiplex PCR and IS6110 typing. Results: The median age of 387 HIV-positive children was 15 months; 98% were BCG immunized. The median age of 344 HIV-positive adults was 32 years; 44% were BCG immunized. Blood cultures were positive for mycobacteria in six children (2%) and 38 adults(11%) (P < 0.001). The six pediatric isolates included five MTBC (40% clustered) and one BCG. The 38 adult isolates included 36 MTBC (16% clustered) and two M. avium complex. Conclusion: Bacteremia due to MTB is less common among children than adults with advanced HIV infection in Zambia. Bacteremia due to M. bovis BCG is rare even among children with recent BCG immunization and symptomatic HIV infection.

AB - Background: Among adults with advanced HIV infection in developing countries, bacteremia due to Mycobacterium tuberculosis (MTB) is common and bacteremia due to M. bovis (bacille Calmette-Guérin; BCG) is rare. Comparable data are not available for children with HIV. Objective: To compare the prevalence of bacteremia due to M. tuberculosis or M. bovis BCG in hospitalized children and adults with HIV infection in a developing country with a high prevalence of tuberculosis and HIV and > 95% BCG immunization coverage. Design: Descriptive cross-sectional study. Methods: Prospectively hospitalized patients in Lusaka, Zambia who were suspected to have HIV infection underwent phlebotomy for HIV ELISA, HIV viral load, and lysiscentrifugation blood culture for mycobacteria. Histories were obtained and patients were examined for BCG scars. Mycobacterial isolates were identified using DNA probes for MTB complex (MTBC), multiplex PCR and IS6110 typing. Results: The median age of 387 HIV-positive children was 15 months; 98% were BCG immunized. The median age of 344 HIV-positive adults was 32 years; 44% were BCG immunized. Blood cultures were positive for mycobacteria in six children (2%) and 38 adults(11%) (P < 0.001). The six pediatric isolates included five MTBC (40% clustered) and one BCG. The 38 adult isolates included 36 MTBC (16% clustered) and two M. avium complex. Conclusion: Bacteremia due to MTB is less common among children than adults with advanced HIV infection in Zambia. Bacteremia due to M. bovis BCG is rare even among children with recent BCG immunization and symptomatic HIV infection.

KW - BCG

KW - Bacille Calmette-Guérin

KW - HIV

KW - Tuberculosis

KW - Zambia

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