Bacteriophage-Induced Modifications of Host RNA Polymerase

Sergei Nechaev, Konstantin Severinov

Research output: Contribution to journalReview article

44 Citations (Scopus)

Abstract

Bacteriophages have developed an impressive array of ingenious mechanisms to modify bacterial host RNA polymerase to make it serve viral needs. In this review we summarize the current knowledge about two types of host RNA polymerase modifications induced by double-stranded DNA phages: covalent modifications and modifications through RNA polymerase-binding proteins. We interpret the biochemical and genetic data within the framework of a structure-function model of bacterial RNA polymerase and viral biology.

Original languageEnglish (US)
Pages (from-to)301-322
Number of pages22
JournalAnnual Review of Microbiology
Volume57
DOIs
StatePublished - Nov 20 2003

Fingerprint

DNA-Directed RNA Polymerases
Bacteriophages
Bacterial RNA
RNA-Binding Proteins
Molecular Biology
DNA

All Science Journal Classification (ASJC) codes

  • Microbiology

Keywords

  • Host transcription shut-off
  • Transcription regulation
  • Viral development

Cite this

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Bacteriophage-Induced Modifications of Host RNA Polymerase. / Nechaev, Sergei; Severinov, Konstantin.

In: Annual Review of Microbiology, Vol. 57, 20.11.2003, p. 301-322.

Research output: Contribution to journalReview article

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T1 - Bacteriophage-Induced Modifications of Host RNA Polymerase

AU - Nechaev, Sergei

AU - Severinov, Konstantin

PY - 2003/11/20

Y1 - 2003/11/20

N2 - Bacteriophages have developed an impressive array of ingenious mechanisms to modify bacterial host RNA polymerase to make it serve viral needs. In this review we summarize the current knowledge about two types of host RNA polymerase modifications induced by double-stranded DNA phages: covalent modifications and modifications through RNA polymerase-binding proteins. We interpret the biochemical and genetic data within the framework of a structure-function model of bacterial RNA polymerase and viral biology.

AB - Bacteriophages have developed an impressive array of ingenious mechanisms to modify bacterial host RNA polymerase to make it serve viral needs. In this review we summarize the current knowledge about two types of host RNA polymerase modifications induced by double-stranded DNA phages: covalent modifications and modifications through RNA polymerase-binding proteins. We interpret the biochemical and genetic data within the framework of a structure-function model of bacterial RNA polymerase and viral biology.

KW - Host transcription shut-off

KW - Transcription regulation

KW - Viral development

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U2 - https://doi.org/10.1146/annurev.micro.57.030502.090942

DO - https://doi.org/10.1146/annurev.micro.57.030502.090942

M3 - Review article

VL - 57

SP - 301

EP - 322

JO - Annual Review of Microbiology

JF - Annual Review of Microbiology

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