Bedaquiline eliminates bactericidal activity of -lactams against mycobacterium abscessus

Marissa Lindman, Thomas Dick

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The -lactams imipenem and cefoxitin are used for the treatment of Mycobacterium abscessus lung infections. Here, we show that these cell wall synthesis inhibitors trigger a lethal bacterial ATP burst by increasing oxidative phosphorylation. Cotreatment of M. abscessus with the antimycobacterial ATP synthase inhibitor bedaquiline suppresses this ATP burst and eliminates the bactericidal activity of -lactams. Thus, the addition of bedaquiline to -lactam-containing regimes may negatively affect treatment outcome.

Original languageEnglish (US)
Article numbere00827-19
JournalAntimicrobial agents and chemotherapy
Volume63
Issue number8
DOIs
StatePublished - 2019

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology

Keywords

  • Bedaquiline
  • Drug-drug interaction
  • Lactam
  • Mycobacterium abscessus

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