Behavioral and histological effects of acrylamide in rainbow trout

Deborah Wissink Petersen; Keith R. Cooper; Marvin A. Friedman; John J. Lech

doi:10.1016/0041-008X(87)90095-0

Behavioral and histological effects of acrylamide in rainbow trout

Deborah Wissink Petersen
, Keith R. Cooper
, Marvin A. Friedman
, John J. Lech

School of Environmental and Biological Sciences, Biochemistry & Microbiology

Rutgers, The State University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A histological and behavioral study was used to assess whether acrylamide produced neurotoxic effects in rainbow trout. Swimming performance of trout exposed to 0, 12.5, or 25 mg/liter acrylamide for 15 days was unaffected. Swimming performance of animals exposed to 50 mg/liter acrylamide for a similar time period was compromised by morbidity and mortality of the animals in this treatment group. The absence of dose-related histological lesions in central neurons, peripheral neurons or muscle suggested that the observed deficit in swimming performance was due to a generalized toxic response. Acrylamide treatment produced dose-related lesions in the gill and liver of rainbow trout.

Original language	American English
Pages (from-to)	177-184
Number of pages	8
Journal	Toxicology and Applied Pharmacology
Volume	87
Issue number	1
DOIs	https://doi.org/10.1016/0041-008X(87)90095-0
State	Published - Jan 1987

ASJC Scopus subject areas

Toxicology
Pharmacology

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10.1016/0041-008X(87)90095-0

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title = "Behavioral and histological effects of acrylamide in rainbow trout",

abstract = "A histological and behavioral study was used to assess whether acrylamide produced neurotoxic effects in rainbow trout. Swimming performance of trout exposed to 0, 12.5, or 25 mg/liter acrylamide for 15 days was unaffected. Swimming performance of animals exposed to 50 mg/liter acrylamide for a similar time period was compromised by morbidity and mortality of the animals in this treatment group. The absence of dose-related histological lesions in central neurons, peripheral neurons or muscle suggested that the observed deficit in swimming performance was due to a generalized toxic response. Acrylamide treatment produced dose-related lesions in the gill and liver of rainbow trout.",

author = "Petersen, \{Deborah Wissink\} and Cooper, \{Keith R.\} and Friedman, \{Marvin A.\} and Lech, \{John J.\}",

note = "Funding Information: The authors thank Mr. Mark Goodrich for his expert technical assistance. This work was supported by American Cyanamid Company and NIH Grants ES01985 and ESO1080.",

year = "1987",

month = jan,

doi = "10.1016/0041-008X(87)90095-0",

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T1 - Behavioral and histological effects of acrylamide in rainbow trout

AU - Petersen, Deborah Wissink

AU - Cooper, Keith R.

AU - Friedman, Marvin A.

AU - Lech, John J.

N1 - Funding Information: The authors thank Mr. Mark Goodrich for his expert technical assistance. This work was supported by American Cyanamid Company and NIH Grants ES01985 and ESO1080.

PY - 1987/1

Y1 - 1987/1

N2 - A histological and behavioral study was used to assess whether acrylamide produced neurotoxic effects in rainbow trout. Swimming performance of trout exposed to 0, 12.5, or 25 mg/liter acrylamide for 15 days was unaffected. Swimming performance of animals exposed to 50 mg/liter acrylamide for a similar time period was compromised by morbidity and mortality of the animals in this treatment group. The absence of dose-related histological lesions in central neurons, peripheral neurons or muscle suggested that the observed deficit in swimming performance was due to a generalized toxic response. Acrylamide treatment produced dose-related lesions in the gill and liver of rainbow trout.

AB - A histological and behavioral study was used to assess whether acrylamide produced neurotoxic effects in rainbow trout. Swimming performance of trout exposed to 0, 12.5, or 25 mg/liter acrylamide for 15 days was unaffected. Swimming performance of animals exposed to 50 mg/liter acrylamide for a similar time period was compromised by morbidity and mortality of the animals in this treatment group. The absence of dose-related histological lesions in central neurons, peripheral neurons or muscle suggested that the observed deficit in swimming performance was due to a generalized toxic response. Acrylamide treatment produced dose-related lesions in the gill and liver of rainbow trout.

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EP - 184

JO - Toxicology and Applied Pharmacology

JF - Toxicology and Applied Pharmacology

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Behavioral and histological effects of acrylamide in rainbow trout

Abstract

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