Beneficial effects of ethanol on experimental burns

J. I. Tikellis, C. R. Spillert, W. Suval, E. J. Lazaro

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2 Scopus citations

Abstract

Alcohol has been demonstrated to produce cutaneous vasodilation. The burn wound is characterized by a compromised microcirculation which is amenable to pharmacologic manipulation to improve the final outcome of the injury. Various agents including heparin, aspirin, nonsteroidal anti-inflammatory agents have been employed to maintain a patent microcirculatory bed. Ethanol has been used in the present study in a murine burn model as a vasodilator administered immediately preburn and postburn. Preburn administration of ethanol significantly improved the mean burn severity at 48 hr compared to ethanol given post-burn. Ethanol, acting as a vasodilator, improves dermal circulation post-burn and reduces the overall extent of the injury.

Original languageAmerican English
Pages (from-to)53-55
Number of pages3
JournalAmerican Surgeon
Volume52
Issue number1
StatePublished - 1986

ASJC Scopus subject areas

  • Surgery

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