Beta-endorphin neuron regulates stress response and innate immunity to prevent breast cancer growth and progression

Dipak K. Sarkar, Changqing Zhang

Research output: Chapter in Book/Report/Conference proceedingChapter

22 Scopus citations

Abstract

Body and mind interact extensively with each other to control health. Emerging evidence suggests that chronic neurobehavioral stress can promote various tumor growth and progression. The biological reaction to stress involves a chemical cascade initiated within the central nervous system and extends to the periphery, encompassing the immune, endocrine, and autonomic systems. Activation of sympathetic nervous system, such as what happens in the "fight or flight" response, downregulates tumor-suppressive genes, inhibits immune function, and promotes tumor growth. On the other hand, an optimistic attitude or psychological intervention helps cancer patients to survive longer via increase in β-endorphin neuronal suppression of stress hormone levels and sympathetic outflows and activation of parasympathetic control of tumor suppressor gene and innate immune cells to destroy and clear tumor cells.

Original languageEnglish (US)
Title of host publicationVitamins and Hormones
PublisherAcademic Press Inc.
Pages263-276
Number of pages14
DOIs
StatePublished - 2013

Publication series

NameVitamins and Hormones
Volume93

ASJC Scopus subject areas

  • Physiology
  • Endocrinology

Keywords

  • Breast cancer
  • Endogenous opioid peptide
  • Innate immunity
  • Oncoimmunology
  • Stress control

Fingerprint

Dive into the research topics of 'Beta-endorphin neuron regulates stress response and innate immunity to prevent breast cancer growth and progression'. Together they form a unique fingerprint.

Cite this