Better to burn out than it is to rust: Coordinating cellular redox states during aging and stress

Christopher Rongo

doi:10.15252/embj.201592504

Better to burn out than it is to rust: Coordinating cellular redox states during aging and stress

Christopher Rongo

Rutgers, The State University

Research output: Contribution to journal › Short survey › peer-review

3 Scopus citations

Abstract

Both the protein homeostasis (proteostasis) and the oxidation/reduction (redox) environment of the cell play critical roles in disease- and age-associated decline, yet the relationship between the two remains mysterious. In this issue of The EMBO Journal, Kirstein et al.() show that both the cytosol and the ER shift their redox states in response to proteotoxic stress and that stress in one compartment can alter redox state in the other. Moreover, proteotoxic stress can induce changes in redox state across tissues, suggesting that an organism-wide surveillance mechanism modulates cellular redox environment. A recent study showing cytosolic and ER redox states to be inversely regulated upon proteotoxic stress sheds further light on the balance between cellular homeostasis and aging.

Original language	American English
Pages (from-to)	2310-2311
Number of pages	2
Journal	EMBO Journal
Volume	34
Issue number	18
DOIs	https://doi.org/10.15252/embj.201592504
State	Published - Sep 1 2015

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

Access to Document

10.15252/embj.201592504

Cite this

@article{fd59ab43d69f4249996d43b97d6b0a98,

title = "Better to burn out than it is to rust: Coordinating cellular redox states during aging and stress",

abstract = "Both the protein homeostasis (proteostasis) and the oxidation/reduction (redox) environment of the cell play critical roles in disease- and age-associated decline, yet the relationship between the two remains mysterious. In this issue of The EMBO Journal, Kirstein et al.() show that both the cytosol and the ER shift their redox states in response to proteotoxic stress and that stress in one compartment can alter redox state in the other. Moreover, proteotoxic stress can induce changes in redox state across tissues, suggesting that an organism-wide surveillance mechanism modulates cellular redox environment. A recent study showing cytosolic and ER redox states to be inversely regulated upon proteotoxic stress sheds further light on the balance between cellular homeostasis and aging.",

author = "Christopher Rongo",

note = "Publisher Copyright: {\textcopyright} 2015 The Author.",

year = "2015",

month = sep,

day = "1",

doi = "10.15252/embj.201592504",

language = "American English",

volume = "34",

pages = "2310--2311",

journal = "EMBO Journal",

issn = "0261-4189",

publisher = "EMBO Press",

number = "18",

}

TY - JOUR

T1 - Better to burn out than it is to rust

T2 - Coordinating cellular redox states during aging and stress

AU - Rongo, Christopher

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Both the protein homeostasis (proteostasis) and the oxidation/reduction (redox) environment of the cell play critical roles in disease- and age-associated decline, yet the relationship between the two remains mysterious. In this issue of The EMBO Journal, Kirstein et al.() show that both the cytosol and the ER shift their redox states in response to proteotoxic stress and that stress in one compartment can alter redox state in the other. Moreover, proteotoxic stress can induce changes in redox state across tissues, suggesting that an organism-wide surveillance mechanism modulates cellular redox environment. A recent study showing cytosolic and ER redox states to be inversely regulated upon proteotoxic stress sheds further light on the balance between cellular homeostasis and aging.

AB - Both the protein homeostasis (proteostasis) and the oxidation/reduction (redox) environment of the cell play critical roles in disease- and age-associated decline, yet the relationship between the two remains mysterious. In this issue of The EMBO Journal, Kirstein et al.() show that both the cytosol and the ER shift their redox states in response to proteotoxic stress and that stress in one compartment can alter redox state in the other. Moreover, proteotoxic stress can induce changes in redox state across tissues, suggesting that an organism-wide surveillance mechanism modulates cellular redox environment. A recent study showing cytosolic and ER redox states to be inversely regulated upon proteotoxic stress sheds further light on the balance between cellular homeostasis and aging.

UR - http://www.scopus.com/inward/record.url?scp=84941732860&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941732860&partnerID=8YFLogxK

U2 - 10.15252/embj.201592504

DO - 10.15252/embj.201592504

M3 - Short survey

C2 - 26232151

SN - 0261-4189

VL - 34

SP - 2310

EP - 2311

JO - EMBO Journal

JF - EMBO Journal

IS - 18

ER -

Better to burn out than it is to rust: Coordinating cellular redox states during aging and stress

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this