Beyond Arthritis: Understanding the Influence of Gout on Erectile Function: A Systematic Review

Kyle Park, Nikhil K. Gupta, Ephrem O. Olweny, Naomi Schlesinger

Research output: Contribution to journalReview articlepeer-review

Abstract

Objective: To review the evidence suggesting a significant association between gout and erectile dysfunction (ED) and evaluate possible underlying pathways that may explain this relationship. Methods: English medical literature was searched from January 1, 2010, to January 1, 2020, for randomized or quasi-randomized controlled trials, cross-sectional studies, case-cohort studies, or meta-analysis evaluating the relationship between gout and ED. Results: All nine gout studies included in the study found a significant association between gout and ED. ED pathophysiology in gout involves hyperuricemia, increased reactive oxygen species, decreased nitric oxide synthesis, and low-grade inflammation. Conclusion: The findings of this review suggest that the effect of urate-lowering therapy on the incidence of ED in gout patients should be studied. Additionally, we propose that all gout patients should be assessed for ED.

Original languageEnglish (US)
JournalUrology
DOIs
StateAccepted/In press - 2020

All Science Journal Classification (ASJC) codes

  • Urology

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