Binary time series modeling with application to adhesion frequency experiments

Ying Hung, Veronika Zarnitsyna, Yan Zhang, Cheng Zhu, C. F.Jeff Wu

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Repeated adhesion frequency assay is the only published method for measuring the kinetic rates of cell adhesion. Cell adhesion plays an important role in many physiological and pathological processes. Traditional analysis of adhesion frequency experiments assumes that the adhesion test cycles are independent Bernoulli trials. This assumption often can be violated in practice. Motivated by the analysis of repeated adhesion tests, a binary time series model incorporating random effects is developed. A goodness-of-fit statistic is introduced to assess the adequacy of distribution assumptions on the dependent binary data with random effects. The asymptotic distribution of the goodness-of-fit statistic is derived, and its finite-sample performance is examined through a simulation study. Application of the proposed methodology to real data from a T-cell experiment reveals some interesting information, including the dependency between repeated adhesion tests.

Original languageEnglish (US)
Pages (from-to)1248-1259
Number of pages12
JournalJournal of the American Statistical Association
Volume103
Issue number483
DOIs
StatePublished - Sep 2008

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Statistics, Probability and Uncertainty

Keywords

  • Cell adhesion
  • Goodness-of-fit test
  • Micropipette experiments
  • Random effects

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