Binding of 2-Hydroxybenzo(a)pyrene to Estrogen Receptors in Rat Cytosol

Richard H. Ebright, James R. Wong, Lan Bo Chen

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The potent carcinogen 2-hydroxybenzo(a)pyrene (2-OH-BP) competes for binding to the estrogen receptor in the cytosol of rat uterus and liver. The dissociation constant (K) for this interaction is ≃2 x 10In contrast, 4-hydroxybenzo(a)pyrene does not bind to the estrogen receptor; 1-hydroxybenzo(a)pyrene 5-hydroxybenzo(a)pyrene, 6-hydroxybenzo-(a)pyrene and 12-hydroxybenzo(a)pyrene bind less tightly than does 2-OH-BP. These five chemicals are not carcinogenic. We suggest that the estrogen receptor may mediate the carcinogenic effect of 2-OH-BP or of related chemicals. One possibility is that the receptor might convey 2-OH-BP to specific sites in DNA.

Original languageAmerican English
Pages (from-to)2349-2351
Number of pages3
JournalCancer Research
Volume46
Issue number5
StatePublished - May 1 1986
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this