Binding of 2-Hydroxybenzo(a)pyrene to Estrogen Receptors in Rat Cytosol

Richard Ebright, James R. Wong, Lan Bo Chen

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The potent carcinogen 2-hydroxybenzo(a)pyrene (2-OH-BP) competes for binding to the estrogen receptor in the cytosol of rat uterus and liver. The dissociation constant (K) for this interaction is ≃2 x 10In contrast, 4-hydroxybenzo(a)pyrene does not bind to the estrogen receptor; 1-hydroxybenzo(a)pyrene 5-hydroxybenzo(a)pyrene, 6-hydroxybenzo-(a)pyrene and 12-hydroxybenzo(a)pyrene bind less tightly than does 2-OH-BP. These five chemicals are not carcinogenic. We suggest that the estrogen receptor may mediate the carcinogenic effect of 2-OH-BP or of related chemicals. One possibility is that the receptor might convey 2-OH-BP to specific sites in DNA.

Original languageEnglish (US)
Pages (from-to)2349-2351
Number of pages3
JournalCancer Research
Volume46
Issue number5
StatePublished - May 1 1986
Externally publishedYes

Fingerprint

Estrogen Receptors
Cytosol
Carcinogens
Uterus
2-hydroxybenzo(a)pyrene
hydroxide ion
Liver
DNA
pyrene

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Ebright, Richard ; Wong, James R. ; Chen, Lan Bo. / Binding of 2-Hydroxybenzo(a)pyrene to Estrogen Receptors in Rat Cytosol. In: Cancer Research. 1986 ; Vol. 46, No. 5. pp. 2349-2351.
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Ebright, R, Wong, JR & Chen, LB 1986, 'Binding of 2-Hydroxybenzo(a)pyrene to Estrogen Receptors in Rat Cytosol', Cancer Research, vol. 46, no. 5, pp. 2349-2351.

Binding of 2-Hydroxybenzo(a)pyrene to Estrogen Receptors in Rat Cytosol. / Ebright, Richard; Wong, James R.; Chen, Lan Bo.

In: Cancer Research, Vol. 46, No. 5, 01.05.1986, p. 2349-2351.

Research output: Contribution to journalArticle

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