Abstract
The potent carcinogen 2-hydroxybenzo(a)pyrene (2-OH-BP) competes for binding to the estrogen receptor in the cytosol of rat uterus and liver. The dissociation constant (K) for this interaction is ≃2 x 10In contrast, 4-hydroxybenzo(a)pyrene does not bind to the estrogen receptor; 1-hydroxybenzo(a)pyrene 5-hydroxybenzo(a)pyrene, 6-hydroxybenzo-(a)pyrene and 12-hydroxybenzo(a)pyrene bind less tightly than does 2-OH-BP. These five chemicals are not carcinogenic. We suggest that the estrogen receptor may mediate the carcinogenic effect of 2-OH-BP or of related chemicals. One possibility is that the receptor might convey 2-OH-BP to specific sites in DNA.
| Original language | American English |
|---|---|
| Pages (from-to) | 2349-2351 |
| Number of pages | 3 |
| Journal | Cancer Research |
| Volume | 46 |
| Issue number | 5 |
| State | Published - May 1 1986 |
| Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research