Biodegradable Janus nanoparticles for local pulmonary delivery of hydrophilic and hydrophobic molecules to the lungs

Olga B. Garbuzenko, Jennifer Winkler, Maria Tomassone, Tamara Minko

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The aim of the present work is to synthesize, characterize, and test self-assembled anisotropic or Janus particles designed to load anticancer drugs for lung cancer treatment by inhalation. The particles were synthesized using binary mixtures of biodegradable and biocompatible materials. The particles did not demonstrate cyto- and genotoxic effects. Janus particles were internalized by cancer cells and accumulated both in the cytoplasm and nuclei. After inhalation delivery, nanoparticles accumulated preferentially in the lungs of mice and retained there for at least 24 h. Two drugs or other biologically active components with substantially different aqueous solubility can be simultaneously loaded in two-phases (polymer-lipid) of these nanoparticles. In the present proof-of-concept investigation, the particles were loaded with two anticancer drugs: doxorubicin and curcumin as model anticancer drugs with relatively high and low aqueous solubility, respectively. However, there are no obstacles for loading any hydrophobic or hydrophilic chemical agents. Nanoparticles with dual load were used for their local inhalation delivery directly to the lungs of mice with orthotopic model of human lung cancer. In vivo experiments showed that the selected nanoparticles with two anticancer drugs with different mechanisms of action prevented progression of lung tumors. It should be stressed that anticancer effects of the combined treatment with two anticancer drugs loaded in the same nanoparticle significantly exceeded the effect of either drug loaded in similar nanoparticles alone.

Original languageEnglish (US)
Pages (from-to)12941-12949
Number of pages9
JournalLangmuir
Volume30
Issue number43
DOIs
StatePublished - Nov 4 2014

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Janus
lungs
delivery
drugs
Nanoparticles
nanoparticles
Molecules
Pharmaceutical Preparations
respiration
molecules
cancer
Solubility
mice
solubility
self tests
Oncology
Curcumin
Binary mixtures
cytoplasm
Biomaterials

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • Materials Science(all)
  • Spectroscopy
  • Surfaces and Interfaces
  • Electrochemistry

Cite this

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Biodegradable Janus nanoparticles for local pulmonary delivery of hydrophilic and hydrophobic molecules to the lungs. / Garbuzenko, Olga B.; Winkler, Jennifer; Tomassone, Maria; Minko, Tamara.

In: Langmuir, Vol. 30, No. 43, 04.11.2014, p. 12941-12949.

Research output: Contribution to journalArticle

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