Biomaterials and scaffolds in reparative medicine

Ellio L. Chaikof, Howard Matthew, Joachim Kohn, Antonio G. Mikos, Glenn D. Prestwich, Christopher M. Yip

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

Most approaches currently pursued or contemplated within the framework of reparative medicine, including cell-based therapies, artificial organs, and engineered living tissues, are dependent on our ability to synthesize or otherwise generate novel materials, fabricate or assemble materials into appropriate 2-D and 3-D forms, and precisely tailor material-related physical and biological properties so as to achieve a desired clinical response. This paper summarizes the scientific and technological opportunities within the fields of biomaterials science and molecular engineering that will likely establish new enabling technologies for cellular and molecular therapies directed at the repair, replacement, or reconstruction of diseased or damaged organs and tissues.

Original languageEnglish (US)
Pages (from-to)96-105
Number of pages10
JournalAnnals of the New York Academy of Sciences
Volume961
DOIs
StatePublished - 2002

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Neuroscience(all)
  • History and Philosophy of Science

Keywords

  • Bioartificial materials
  • Bioengineered scaffolds
  • Tissue repair

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