Biomimetic antimicrobial polymers—Design, characterization, antimicrobial, and novel applications

Haruko Takahashi, Iva Sovadinova, Kazuma Yasuhara, Satyavani Vemparala, Gregory A. Caputo, Kenichi Kuroda

Research output: Contribution to journalReview articlepeer-review


Biomimetic antimicrobial polymers have been an area of great interest as the need for novel antimicrobial compounds grows due to the development of resistance. These polymers were designed and developed to mimic naturally occurring antimicrobial peptides in both physicochemical composition and mechanism of action. These antimicrobial peptide mimetic polymers have been extensively investigated using chemical, biophysical, microbiological, and computational approaches to gain a deeper understanding of the molecular interactions that drive function. These studies have helped inform SARs, mechanism of action, and general physicochemical factors that influence the activity and properties of antimicrobial polymers. However, there are still lingering questions in this field regarding 3D structural patterning, bioavailability, and applicability to alternative targets. In this review, we present a perspective on the development and characterization of several antimicrobial polymers and discuss novel applications of these molecules emerging in the field. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease.

Original languageEnglish (US)
Article numbere1866
JournalWiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
Issue number3
StatePublished - May 1 2023

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering


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