TY - JOUR
T1 - Biomimetic Compartments Scaffolded by Nucleic Acid Nanostructures
AU - Fu, Jinglin
AU - Oh, Sung Won
AU - Monckton, Kristin
AU - Arbuckle-Keil, Georgia
AU - Ke, Yonggang
AU - Zhang, Ting
N1 - Funding Information: This work was supported by an Army Research Office YIP award to J.F. (W911NF-14-1-0434) and DoD DURIP (W911NF-16-1-0220). J.F. was also supported by the start-up funds from Rutgers University-Camden. K.M. was sponsored by Arts and Sciences Dean’s Undergraduate Research Grant at Rutgers-Camden. The authors are also grateful to the Equipment Leasing Funds from the State of New Jersey. The authors also appreciate the helpful discussion from Dr. Chenxiang Lin. Funding Information: This work was supported by an Army Research Office YIP award to J.F. (W911NF-14-1-0434) and DoD DURIP (W911NF-16-1-0220). J.F. was also supported by the start-up funds from Rutgers University-Camden. K.M. was sponsored by Arts and Sciences Dean's Undergraduate Research Grant at Rutgers-Camden. The authors are also grateful to the Equipment Leasing Funds from the State of New Jersey. The authors also appreciate the helpful discussion from Dr. Chenxiang Lin. Publisher Copyright: © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2019/6/26
Y1 - 2019/6/26
N2 - The behaviors of living cells are governed by a series of regulated and confined biochemical reactions. The design and successful construction of synthetic cellular reactors can be useful in a broad range of applications that will bring significant scientific and economic impact. Over the past few decades, DNA self-assembly has enabled the design and fabrication of sophisticated 1D, 2D, and 3D nanostructures, and is applied to organizing a variety of biomolecular components into prescribed 2D and 3D patterns. In this Concept, the recent and exciting progress in DNA-scaffolded compartmentalizations and their applications in enzyme encapsulation, lipid membrane assembly, artificial transmembrane nanopores, and smart drug delivery are in focus. Taking advantage of these features promises to deliver breakthroughs toward the attainment of new synthetic and biomimetic reactors.
AB - The behaviors of living cells are governed by a series of regulated and confined biochemical reactions. The design and successful construction of synthetic cellular reactors can be useful in a broad range of applications that will bring significant scientific and economic impact. Over the past few decades, DNA self-assembly has enabled the design and fabrication of sophisticated 1D, 2D, and 3D nanostructures, and is applied to organizing a variety of biomolecular components into prescribed 2D and 3D patterns. In this Concept, the recent and exciting progress in DNA-scaffolded compartmentalizations and their applications in enzyme encapsulation, lipid membrane assembly, artificial transmembrane nanopores, and smart drug delivery are in focus. Taking advantage of these features promises to deliver breakthroughs toward the attainment of new synthetic and biomimetic reactors.
KW - DNA nanocaged enzymes
KW - DNA-confined lipid membranes
KW - DNA-scaffolded assembly
KW - smart drug delivery
KW - synthetic reactors
UR - http://www.scopus.com/inward/record.url?scp=85070727801&partnerID=8YFLogxK
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U2 - https://doi.org/10.1002/smll.201900256
DO - https://doi.org/10.1002/smll.201900256
M3 - Article
C2 - 30884139
SN - 1613-6810
VL - 15
JO - Small
JF - Small
IS - 26
M1 - 1900256
ER -