Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor

Thomas Dobner, Nobuo Horikoshi, Susanne Rubenwolf, Thomas Eugene Shenk

Research output: Contribution to journalArticle

242 Citations (Scopus)

Abstract

The adenovirus E4orf6 protein is shown here to interact with the cellular tumor suppressor protein p53 and to block p53-mediated transcriptional activation. The adenovirus protein inhibited the ability of p53 to bind to human TAF(II)31, a component of transcription factor IID (TFIID). Earlier work demonstrated that the interaction of p53 with TAF(II)31 involves a sequence near the NH2-terminus of p53, whereas the E4orf6-p53 interaction occurs within amino acids 318 to 360 of p53. Thus, the E4orf6 protein interacts at a site on p53 distinct from the domain that binds to TAF(II)31 but nevertheless inhibits the p53-TAF(II)31 interaction.

Original languageEnglish (US)
Pages (from-to)1470-1473
Number of pages4
JournalScience
Volume272
Issue number5267
DOIs
StatePublished - Jan 1 1996

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Adenoviridae
Transcriptional Activation
Transcription Factor TFIID
Tumor Suppressor Protein p53
Neoplasms
Proteins
Amino Acids
adenovirus E4orf6 protein

All Science Journal Classification (ASJC) codes

  • General

Cite this

Dobner, Thomas ; Horikoshi, Nobuo ; Rubenwolf, Susanne ; Shenk, Thomas Eugene. / Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor. In: Science. 1996 ; Vol. 272, No. 5267. pp. 1470-1473.
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Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumor suppressor. / Dobner, Thomas; Horikoshi, Nobuo; Rubenwolf, Susanne; Shenk, Thomas Eugene.

In: Science, Vol. 272, No. 5267, 01.01.1996, p. 1470-1473.

Research output: Contribution to journalArticle

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AB - The adenovirus E4orf6 protein is shown here to interact with the cellular tumor suppressor protein p53 and to block p53-mediated transcriptional activation. The adenovirus protein inhibited the ability of p53 to bind to human TAF(II)31, a component of transcription factor IID (TFIID). Earlier work demonstrated that the interaction of p53 with TAF(II)31 involves a sequence near the NH2-terminus of p53, whereas the E4orf6-p53 interaction occurs within amino acids 318 to 360 of p53. Thus, the E4orf6 protein interacts at a site on p53 distinct from the domain that binds to TAF(II)31 but nevertheless inhibits the p53-TAF(II)31 interaction.

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