Abstract
The blood-brain barrier (BBB), as the name implies, is a barrier formed by a selective semipermeable membrane that provides interface between the cerebral circulating blood from the cerebral extracellular fluid within the central nervous system. This barrier is important for the continuation of brain homeostasis, its safety, and regulation of efflux and influx transfer. Disruption of this BBB presents a pathological hallmark as a result of number of neuroinflammatory events. This chapter reviews the existing literature on the anatomy and physiological processes of the BBB in general, and the characteristic disruption of this barrier during neuroinflammation mechanism in special. Understanding of BBB disruption holds considerable promise for the management and avoidance of neurological illnesses.
| Original language | American English |
|---|---|
| Title of host publication | Neuroinflammation |
| Publisher | Elsevier |
| Pages | 529-539 |
| Number of pages | 11 |
| ISBN (Electronic) | 9780128117095 |
| ISBN (Print) | 9780128117248 |
| DOIs | |
| State | Published - Jan 1 2018 |
| Externally published | Yes |
ASJC Scopus subject areas
- General Medicine
Keywords
- Blood-brain barrier
- endothelial cells
- microglia
- multiple sclerosis
- neuroinflammation